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    Gpx3 glutathione peroxidase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64317, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gpx3provided by RGD
    Official Full Name
    glutathione peroxidase 3provided by RGD
    Primary source
    RGD:69224
    See related
    EnsemblRapid:ENSRNOG00000052564 AllianceGenome:RGD:69224
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gpxp; GPx-3; GPx-P; GSHPx-3; GSHPx-P
    Summary
    The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted and is predominantly expressed in rat kidney, which appears to be the major source of the enzyme in plasma. Dysregulation of this isozyme has been associated with obesity-related metabolic complications. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Aug 2016]
    Expression
    Restricted expression toward (RPKM 17670.6) See more
    Orthologs
    NEW
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    Genomic context

    See Gpx3 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (39529335..39537406)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (39028624..39036695)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (40247436..40255423)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene LYR motif containing 7 Neighboring gene histidine triad nucleotide binding protein 1 Neighboring gene TNFAIP3 interacting protein 1 Neighboring gene 60S ribosomal protein L13-like Neighboring gene annexin A6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glutathione peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glutathione peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutathione peroxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables mercury ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables selenium binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables selenium binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables selenium binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables selenium binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in hydrogen peroxide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within hydrogen peroxide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to corticosterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to molecule of fungal origin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to selenium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    glutathione peroxidase 3
    Names
    plasma glutathione peroxidase
    NP_071970.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022525.4NP_071970.2  glutathione peroxidase 3 precursor

      See identical proteins and their annotated locations for NP_071970.2

      Status: REVIEWED

      Source sequence(s)
      CK477403, FM059908, FM066296, FM066354, FM067533, JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P23764, Q6P6H2
      Related
      ENSRNOP00000110052.1, ENSRNOT00000112041.2
      Conserved Domains (1) summary
      cd00340
      Location:39211
      GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      39529335..39537406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)