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    Ahsg alpha-2-HS-glycoprotein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25373, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ahsgprovided by RGD
    Official Full Name
    alpha-2-HS-glycoproteinprovided by RGD
    Primary source
    RGD:2075
    See related
    EnsemblRapid:ENSRNOG00000038370 AllianceGenome:RGD:2075
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    BSP; pp63; Aa2-066
    Summary
    Enables receptor signaling protein tyrosine kinase inhibitor activity. Involved in several processes, including negative regulation of bone mineralization; negative regulation of insulin receptor signaling pathway; and positive regulation of bone resorption. Located in collagen-containing extracellular matrix and extracellular space. Part of protein-containing complex. Human ortholog(s) of this gene implicated in alopecia-mental retardation syndrome 1; coronary artery disease; and type 2 diabetes mellitus. Orthologous to human AHSG (alpha 2-HS glycoprotein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 58470.4) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ahsg in Genome Data Viewer
    Location:
    11q23
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (91625975..91632583, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (78121388..78127998, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (81711269..81717594, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene histidine-rich glycoprotein Neighboring gene fetuin B Neighboring gene DnaJ heat shock protein family (Hsp40) member B11 Neighboring gene TBCC domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables kinase inhibitor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables receptor signaling protein tyrosine kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in acute-phase response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in acute-phase response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in acute-phase response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in animal organ regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to insulin stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cerebral cortex development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of bone mineralization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of bone mineralization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within ossification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein-containing complex assembly IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in collagen-containing extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    alpha-2-HS-glycoprotein
    Names
    59 kDa bone sialic acid-containing protein
    alpha 2 HS-glycoprotein alpha 2 (fetuin)
    fetuin-A
    glycoprotein PP63
    phosphorylated N-glycoprotein pp63

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012898.6NP_037030.2  alpha-2-HS-glycoprotein precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      P24090, Q5BKD2
      UniProtKB/TrEMBL
      A6JS49, F1LM19
      Related
      ENSRNOP00000055223.5, ENSRNOT00000058422.6
      Conserved Domains (2) summary
      smart00043
      Location:26133
      CY; Cystatin-like domain
      pfam00031
      Location:149237
      Cystatin; Cystatin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      91625975..91632583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)