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    Slc5a1 solute carrier family 5 member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25552, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc5a1provided by RGD
    Official Full Name
    solute carrier family 5 member 1provided by RGD
    Primary source
    RGD:3713
    See related
    EnsemblRapid:ENSRNOG00000017775 AllianceGenome:RGD:3713
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SGLT1; SGLT1a
    Summary
    Enables D-glucose:sodium symporter activity. Predicted to be involved in several processes, including D-glucose transmembrane transport; alpha-glucoside transport; and intestinal D-glucose absorption. Predicted to act upstream of or within D-glucose transmembrane transport; intestinal absorption; and metanephros development. Located in apical plasma membrane; brush border membrane; and cell-cell junction. Human ortholog(s) of this gene implicated in glucose-galactose malabsorption. Orthologous to human SLC5A1 (solute carrier family 5 member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 121.6) and Lung (RPKM 51.7) See more
    Orthologs
    NEW
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    Genomic context

    See Slc5a1 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (81778495..81843084, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (77553990..77618589, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (82910448..82975303, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene C-terminal binding protein 1 Neighboring gene spondin 2 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC93553

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables D-glucose transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables D-glucose:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables D-glucose:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables D-glucose:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables D-glucose:sodium symporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables alpha-glucoside transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables galactose:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables galactose:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables water transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables water transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in D-glucose import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within D-glucose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in D-glucose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in D-glucose transmembrane transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in alpha-glucoside transport ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in chloride transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in galactose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intestinal D-glucose absorption ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intestinal D-glucose absorption ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intestinal D-glucose absorption TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within intestinal absorption ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intestinal absorption TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within metanephros development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in renal D-glucose absorption ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in renal D-glucose absorption ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sodium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transepithelial water transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transport across blood-brain barrier ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    sodium/glucose cotransporter 1
    Names
    Na(+)/glucose cotransporter 1
    Solute carrier family 5, member alpha 1 (Na+/glucose cotransporter)
    high affinity sodium-glucose cotransporter
    solute carrier family 5 (sodium/glucose cotransporter), member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013033.2NP_037165.1  sodium/glucose cotransporter 1

      See identical proteins and their annotated locations for NP_037165.1

      Status: PROVISIONAL

      Source sequence(s)
      D16101
      UniProtKB/Swiss-Prot
      P53790, P97787
      UniProtKB/TrEMBL
      A6IK69, A6IK70
      Related
      ENSRNOP00000024165.5, ENSRNOT00000024165.8
      Conserved Domains (1) summary
      cl00456
      Location:27665
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      81778495..81843084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)