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    Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25576, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ywhahprovided by RGD
    Official Full Name
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, etaprovided by RGD
    Primary source
    RGD:3978
    See related
    EnsemblRapid:ENSRNOG00000055471 AllianceGenome:RGD:3978
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    14-3-3e
    Summary
    Predicted to enable several functions, including nuclear glucocorticoid receptor binding activity; protein heterodimerization activity; and transmembrane transporter binding activity. Predicted to be involved in several processes, including glucocorticoid catabolic process; nuclear receptor-mediated glucocorticoid signaling pathway; and substantia nigra development. Predicted to act upstream of or within intracellular protein transport and negative regulation of dendrite morphogenesis. Is active in synapse. Orthologous to human YWHAH (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 2168.2), Heart (RPKM 817.4) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ywhah in Genome Data Viewer
    Location:
    14q21
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (81920819..81930202, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (77696332..77705715, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (83053041..83062424, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 5 member 1 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene uncharacterized LOC120096506 Neighboring gene uncharacterized LOC134481862 Neighboring gene DEP domain containing 5, GATOR1 subcomplex subunit Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC93547

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear glucocorticoid receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear glucocorticoid receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sodium channel regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sodium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sodium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in glucocorticoid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glucocorticoid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane depolarization during action potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membrane depolarization during action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane depolarization during action potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear receptor-mediated glucocorticoid signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nuclear receptor-mediated glucocorticoid signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in presynaptic modulation of chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in presynaptic modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of sodium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of sodium ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of sodium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in substantia nigra development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cerebellar granule cell to Purkinje cell synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cerebellar granule cell to Purkinje cell synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    14-3-3 protein eta
    Names
    14-3-3 protein eta-subtype
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013052.2NP_037184.1  14-3-3 protein eta

      See identical proteins and their annotated locations for NP_037184.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      P68511
      UniProtKB/TrEMBL
      A0A0G2K2B8, A6IK71
      Related
      ENSRNOP00000075701.1, ENSRNOT00000085735.3
      Conserved Domains (1) summary
      cd10025
      Location:3241
      14-3-3_eta; 14-3-3 eta, an isoform of 14-3-3 protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      81920819..81930202 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)