U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Gabrr3 gamma-aminobutyric acid type A receptor subunit rho3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192258, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gabrr3provided by RGD
    Official Full Name
    gamma-aminobutyric acid type A receptor subunit rho3provided by RGD
    Primary source
    RGD:621564
    See related
    EnsemblRapid:ENSRNOG00000001679 AllianceGenome:RGD:621564
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables GABA-A receptor activity; GABA-gated chloride ion channel activity; and protein domain specific binding activity. Predicted to be involved in chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to be part of GABA-A receptor complex and transmembrane transporter complex. Predicted to be active in GABA-ergic synapse; neuron projection; and postsynaptic membrane. Orthologous to human GABRR3 (gamma-aminobutyric acid type A receptor subunit rho3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 5.8), Thymus (RPKM 4.7) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gabrr3 in Genome Data Viewer
    Location:
    11q12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (54372017..54424466, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (40902812..40955263, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (43046987..43099754, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene crystallin beta-gamma domain containing 3 Neighboring gene ribosomal oxygenase 2 Neighboring gene NLR family, pyrin domain containing 4A, pseudogene 1 Neighboring gene uncharacterized LOC134480985 Neighboring gene olfactory receptor family 5 subfamily AC member 25 Neighboring gene olfactory receptor family 5 subfamily AC member 24

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GABA-A receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GABA-A receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GABA-gated chloride ion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of GABA-A receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    gamma-aminobutyric acid receptor subunit rho-3
    Names
    GABA receptor rho-3 subunit
    GABA(A) receptor subunit rho-3
    GABA(C) receptor
    GABAAR subunit rho-3
    gamma-aminobutyric acid (GABA) A receptor, rho 3
    gamma-aminobutyric acid (GABA) receptor, rho 3
    gamma-aminobutyric acid type A receptor rho3 subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138897.2NP_620252.1  gamma-aminobutyric acid receptor subunit rho-3 precursor

      See identical proteins and their annotated locations for NP_620252.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      P50573
      UniProtKB/TrEMBL
      A6IQJ1
      Related
      ENSRNOP00000002281.4, ENSRNOT00000002281.6
      Conserved Domains (3) summary
      TIGR00860
      Location:58463
      LIC; Cation transporter family protein
      cd03558
      Location:181195
      LGIC_ECD; Cys-loop [structural motif]
      cl28912
      Location:79264
      LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      54372017..54424466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)