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    Rhoa ras homolog family member A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117273, updated on 3-Dec-2024

    Summary

    Official Symbol
    Rhoaprovided by RGD
    Official Full Name
    ras homolog family member Aprovided by RGD
    Primary source
    RGD:619921
    See related
    EnsemblRapid:ENSRNOG00000050519 AllianceGenome:RGD:619921
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Arha; Arha2
    Summary
    Enables several functions, including GTPase activity; Rho GDP-dissociation inhibitor binding activity; and guanyl ribonucleotide binding activity. Involved in several processes, including negative regulation of canonical NF-kappaB signal transduction; positive regulation of protein metabolic process; and regulation of neuron projection development. Acts upstream of or within Rho protein signal transduction; negative regulation of vascular associated smooth muscle cell migration; and negative regulation of vascular associated smooth muscle cell proliferation. Located in several cellular components, including axon; dendritic spine; and neuronal cell body. Used to study membranous glomerulonephritis. Biomarker of artery disease (multiple); asthma; fetal alcohol syndrome; and obesity. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human RHOA (ras homolog family member A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 1085.0), Kidney (RPKM 887.2) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rhoa in Genome Data Viewer
    Location:
    8q32
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (117870548..117904303)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (108991926..109025746)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117082440..117116244)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene dystroglycan 1 Neighboring gene small nuclear ribonucleoprotein D2 polypeptide, pseudogene 3 Neighboring gene nicolin 1, tubulin polyglutamylase complex subunit Neighboring gene U6 snRNA-associated Sm-like protein LSm3 Neighboring gene aminomethyltransferase Neighboring gene T-cell leukemia translocation altered Neighboring gene ribosomal protein S15a, pseudogene 7 Neighboring gene glutathione peroxidase 1 Neighboring gene ubiquitin specific peptidase 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC72339

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GDP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables Rho GDP-dissociation inhibitor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables membrane scission GTPase motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in GTP metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in Roundabout signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Roundabout signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Roundabout signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in actin cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in alpha-beta T cell lineage commitment ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in aortic valve formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in aortic valve formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apical junction assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apical junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apical junction assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in apolipoprotein A-I-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apolipoprotein A-I-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in beta selection ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bone trabecula morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell junction assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to chemokine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to chemokine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to chemokine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to progesterone stimulus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within cerebral cortex cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cleavage furrow formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cleavage furrow formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cytoplasmic microtubule organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytoplasmic microtubule organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryonic cleavage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endothelial tube lumen extension IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within endothelial tube lumen extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of epithelial cell apical/basal polarity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of epithelial cell apical/basal polarity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of epithelial cell apical/basal polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in establishment or maintenance of actin cytoskeleton polarity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within forebrain radial glial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in meiotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic cleavage furrow formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic cleavage furrow formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cleavage furrow formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic spindle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of motor neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell migration involved in sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell size IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of intracellular steroid hormone receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of motor neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuron projection development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of oxidative phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection morphogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in odontogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ossification involved in bone maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in polar body extrusion after meiotic divisions ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of T cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of alpha-beta T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell adhesion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in positive regulation of cell growth IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell migration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in positive regulation of cytokinesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytokinesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of leukocyte adhesion to vascular endothelial cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of leukocyte adhesion to vascular endothelial cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of podosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of stress fiber assembly IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of vascular associated smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vasoconstriction IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of actin polymerization or depolymerization IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in regulation of calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of modification of postsynaptic actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of modification of postsynaptic actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of modification of postsynaptic structure ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of osteoblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of systemic arterial blood pressure by endothelin ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to amino acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to glucocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to glucose IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in semaphorin-plexin signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal muscle satellite cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within skeletal muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spindle localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stress fiber assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in stress fiber assembly IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stress fiber assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in stress-activated protein kinase signaling cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in substantia nigra development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in substrate adhesion-dependent cell spreading IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in wound healing, spreading of cells ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in apical junction complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical junction complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical junction complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell cortex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cleavage furrow IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cleavage furrow IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cleavage furrow ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in meiotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transforming protein RhoA
    Names
    plysia ras-related homolog A2
    ras homolog gene family, member A
    NP_476473.1
    XP_006243761.1
    XP_006243762.1
    XP_006243763.1
    XP_038936642.1
    XP_063120856.1
    XP_063120857.1
    XP_063120858.1
    XP_063120859.1
    XP_063120860.1
    XP_063120861.1
    XP_063120862.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057132.3NP_476473.1  transforming protein RhoA

      See identical proteins and their annotated locations for NP_476473.1

      Status: PROVISIONAL

      Source sequence(s)
      AY026068
      UniProtKB/Swiss-Prot
      P61589
      UniProtKB/TrEMBL
      A0A8I6AFP1, A6I347
      Conserved Domains (1) summary
      cd01870
      Location:5179
      RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      117870548..117904303
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264790.1XP_063120860.1  transforming protein RhoA isoform X1

      UniProtKB/Swiss-Prot
      P61589
      UniProtKB/TrEMBL
      A0A8I6AFP1, A6I347
    2. XM_063264789.1XP_063120859.1  transforming protein RhoA isoform X1

      UniProtKB/Swiss-Prot
      P61589
      UniProtKB/TrEMBL
      A0A8I6AFP1, A6I347
    3. XM_006243700.3XP_006243762.1  transforming protein RhoA isoform X1

      See identical proteins and their annotated locations for XP_006243762.1

      UniProtKB/Swiss-Prot
      P61589
      UniProtKB/TrEMBL
      A0A8I6AFP1, A6I347
      Conserved Domains (1) summary
      cd01870
      Location:5179
      RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
    4. XM_063264786.1XP_063120856.1  transforming protein RhoA isoform X1

      UniProtKB/Swiss-Prot
      P61589
      UniProtKB/TrEMBL
      A0A8I6AFP1, A6I347
      Related
      ENSRNOP00000091658.1, ENSRNOT00000094929.2
    5. XM_063264788.1XP_063120858.1  transforming protein RhoA isoform X1

      UniProtKB/Swiss-Prot
      P61589
      UniProtKB/TrEMBL
      A0A8I6AFP1, A6I347
    6. XM_063264787.1XP_063120857.1  transforming protein RhoA isoform X1

      UniProtKB/Swiss-Prot
      P61589
      UniProtKB/TrEMBL
      A0A8I6AFP1, A6I347
    7. XM_006243699.3XP_006243761.1  transforming protein RhoA isoform X1

      See identical proteins and their annotated locations for XP_006243761.1

      UniProtKB/Swiss-Prot
      P61589
      UniProtKB/TrEMBL
      A0A8I6AFP1, A6I347
      Conserved Domains (1) summary
      cd01870
      Location:5179
      RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
    8. XM_063264792.1XP_063120862.1  transforming protein RhoA isoform X1

      UniProtKB/Swiss-Prot
      P61589
      UniProtKB/TrEMBL
      A0A8I6AFP1, A6I347
    9. XM_039080714.2XP_038936642.1  transforming protein RhoA isoform X1

      UniProtKB/Swiss-Prot
      P61589
      UniProtKB/TrEMBL
      A0A8I6AFP1, A6I347
      Conserved Domains (1) summary
      cd01870
      Location:5179
      RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
    10. XM_063264791.1XP_063120861.1  transforming protein RhoA isoform X1

      UniProtKB/Swiss-Prot
      P61589
      UniProtKB/TrEMBL
      A0A8I6AFP1, A6I347
    11. XM_006243701.2XP_006243763.1  transforming protein RhoA isoform X1

      See identical proteins and their annotated locations for XP_006243763.1

      UniProtKB/Swiss-Prot
      P61589
      UniProtKB/TrEMBL
      A0A8I6AFP1, A6I347
      Conserved Domains (1) summary
      cd01870
      Location:5179
      RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC