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    Dlst dihydrolipoamide S-succinyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299201, updated on 27-Nov-2024

    Summary

    Official Symbol
    Dlstprovided by RGD
    Official Full Name
    dihydrolipoamide S-succinyltransferaseprovided by RGD
    Primary source
    RGD:1359615
    See related
    EnsemblRapid:ENSRNOG00000005061 AllianceGenome:RGD:1359615
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables dihydrolipoyllysine-residue succinyltransferase activity; heat shock protein binding activity; and protein-folding chaperone binding activity. Involved in 2-oxoglutarate metabolic process and NADH metabolic process. Part of oxoglutarate dehydrogenase complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 866.4), Kidney (RPKM 659.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Dlst in Genome Data Viewer
    Location:
    6q31
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (110489576..110512841)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (104758511..104783296)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (108936534..108961322)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene YLP motif containing 1 Neighboring gene small nucleolar RNA U13 Neighboring gene U4 spliceosomal RNA Neighboring gene prospero homeobox 2 Neighboring gene ribosomal protein S6 kinase-like 1 Neighboring gene placental growth factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC95077

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in 2-oxoglutarate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in 2-oxoglutarate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-lysine catabolic process to acetyl-CoA via saccharopine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in NADH metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in succinyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in succinyl-CoA metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tricarboxylic acid cycle IC
    Inferred by Curator
    more info
    PubMed 
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tricarboxylic acid cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tricarboxylic acid cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of catalytic complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of oxoadipate dehydrogenase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of oxoadipate dehydrogenase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of oxoglutarate dehydrogenase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of oxoglutarate dehydrogenase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of oxoglutarate dehydrogenase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
    Names
    2-oxoglutarate dehydrogenase complex component E2
    E2
    E2K
    OGDC-E2
    dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
    dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex
    NP_001006982.2
    XP_006240368.1
    XP_008762978.1
    XP_038967973.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006981.2NP_001006982.2  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

      See identical proteins and their annotated locations for NP_001006982.2

      Status: VALIDATED

      Source sequence(s)
      BC083858, CB807447, CK355938, CK845707
      UniProtKB/Swiss-Prot
      Q01205, Q5XI35
      UniProtKB/TrEMBL
      A6JE02, G3V6P2
      Related
      ENSRNOP00000007298.4, ENSRNOT00000007298.6
      Conserved Domains (3) summary
      cd06849
      Location:72144
      lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
      TIGR01347
      Location:72454
      sucB; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component)
      pfam00198
      Location:239452
      2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      110489576..110512841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240306.3XP_006240368.1  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q8CJG5
      Related
      ENSRNOP00000109609.1, ENSRNOT00000142994.1
      Conserved Domains (3) summary
      cd06849
      Location:97169
      lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
      TIGR01347
      Location:97479
      sucB; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component)
      pfam00198
      Location:264477
      2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
    2. XM_008764756.3XP_008762978.1  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform X3

      UniProtKB/TrEMBL
      D0VYQ0
      Conserved Domains (1) summary
      pfam00198
      Location:55268
      2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
    3. XM_039112045.2XP_038967973.1  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform X2

      UniProtKB/Swiss-Prot
      Q01205, Q5XI35
      UniProtKB/TrEMBL
      Q8CJG5
      Conserved Domains (1) summary
      TIGR01347
      Location:25407
      sucB; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component)