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    Cpt2 carnitine palmitoyltransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25413, updated on 3-Dec-2024

    Summary

    Official Symbol
    Cpt2provided by RGD
    Official Full Name
    carnitine palmitoyltransferase 2provided by RGD
    Primary source
    RGD:2398
    See related
    EnsemblRapid:ENSRNOG00000012443 AllianceGenome:RGD:2398
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CPTII
    Summary
    Enables carnitine O-palmitoyltransferase activity. Involved in fatty acid beta-oxidation and response to fatty acid. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in brain disease; lipid metabolism disorder; and muscular disease. Orthologous to human CPT2 (carnitine palmitoyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 712.7), Adrenal (RPKM 449.7) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cpt2 in Genome Data Viewer
    Location:
    5q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (127893450..127911347, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (122664677..122682126, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (127505646..127523016, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene LDL receptor related protein 8 Neighboring gene mago homolog, exon junction complex subunit Neighboring gene CXXC motif containing zinc binding protein Neighboring gene uncharacterized LOC134486962 Neighboring gene zinc finger CCCH-type containing, antiviral 1, pseudogene 9 Neighboring gene small nucleolar RNA SNORA2/SNORA34 family

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables carnitine O-octanoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables carnitine O-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables carnitine O-palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables carnitine O-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables carnitine O-palmitoyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables carnitine O-palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in carnitine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in carnitine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in carnitine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fatty acid beta-oxidation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid beta-oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fatty acid beta-oxidation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in long-chain fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in long-chain fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in long-chain fatty acid transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in response to fatty acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    carnitine O-palmitoyltransferase 2, mitochondrial
    Names
    carnitine palmitoyltransferase II
    XP_038965227.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429334.1NP_001416263.1  carnitine O-palmitoyltransferase 2, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P18886, P97781
    2. NM_001429335.1NP_001416264.1  carnitine O-palmitoyltransferase 2, mitochondrial isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P18886, P97781
    3. NM_001429336.1NP_001416265.1  carnitine O-palmitoyltransferase 2, mitochondrial isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I5ZW87
    4. NM_012930.2NP_037062.2  carnitine O-palmitoyltransferase 2, mitochondrial isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P18886, P97781
      UniProtKB/TrEMBL
      A6JYT6, G3V7N5
      Related
      ENSRNOP00000016954.1, ENSRNOT00000016954.5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      127893450..127911347 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109299.2XP_038965227.1  carnitine O-palmitoyltransferase 2, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam00755
      Location:49584
      Carn_acyltransf; Choline/Carnitine o-acyltransferase