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    Ppp1r1a protein phosphatase 1, regulatory (inhibitor) subunit 1A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58977, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ppp1r1aprovided by RGD
    Official Full Name
    protein phosphatase 1, regulatory (inhibitor) subunit 1Aprovided by RGD
    Primary source
    RGD:62018
    See related
    EnsemblRapid:ENSRNOG00000036827 AllianceGenome:RGD:62018
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein phosphatase inhibitor activity. Predicted to be involved in intracellular signal transduction. Located in extracellular space. Orthologous to human PPP1R1A (protein phosphatase 1 regulatory inhibitor subunit 1A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 356.5), Kidney (RPKM 325.1) and 3 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ppp1r1a in Genome Data Viewer
    Location:
    7q36
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (136533031..136540687, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (134654578..134662236, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (145146480..145154131, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene NCK associated protein 1 like Neighboring gene uncharacterized LOC134479586 Neighboring gene phosphodiesterase 1B Neighboring gene glycosylation dependent cell adhesion molecule 1 Neighboring gene uncharacterized LOC102547969

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in glycogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein phosphatase 1 regulatory subunit 1A
    Names
    I-1
    IPP-1
    PP1 inhibitor 1
    protein phosphatase inhibitor 1
    NP_073167.1
    XP_006242499.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022676.3NP_073167.1  protein phosphatase 1 regulatory subunit 1A

      See identical proteins and their annotated locations for NP_073167.1

      Status: PROVISIONAL

      Source sequence(s)
      AY648296
      UniProtKB/Swiss-Prot
      P19103, Q6DSU5
      UniProtKB/TrEMBL
      A6KD15, A6KD17
      Related
      ENSRNOP00000052146.2, ENSRNOT00000055271.4
      Conserved Domains (1) summary
      pfam05395
      Location:5142
      DARPP-32; Protein phosphatase inhibitor 1/DARPP-32

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      136533031..136540687 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242437.5XP_006242499.1  protein phosphatase 1 regulatory subunit 1A isoform X1

      UniProtKB/TrEMBL
      A6KD15
      Conserved Domains (1) summary
      pfam05395
      Location:5141
      DARPP-32; Protein phosphatase inhibitor 1/DARPP-32