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    Pigr polymeric immunoglobulin receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25046, updated on 3-Dec-2024

    Summary

    Official Symbol
    Pigrprovided by RGD
    Official Full Name
    polymeric immunoglobulin receptorprovided by RGD
    Primary source
    RGD:3328
    See related
    EnsemblRapid:ENSRNOG00000004405 AllianceGenome:RGD:3328
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    pIgA-R; RNPIGR2
    Summary
    Enables epidermal growth factor receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; detection of chemical stimulus involved in sensory perception of bitter taste; and immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor. Located in recycling endosome membrane. Orthologous to human PIGR (polymeric immunoglobulin receptor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 1995.5), Lung (RPKM 458.8) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Pigr in Genome Data Viewer
    Location:
    13q13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (44851001..44879143)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (42298905..42326877)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (47564176..47592093)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 1 open reading frame 116 Neighboring gene Fc alpha and mu receptor Neighboring gene Fc mu receptor Neighboring gene interleukin 24

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables epidermal growth factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables polymeric immunoglobulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables polymeric immunoglobulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables polymeric immunoglobulin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables polymeric immunoglobulin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in Fc receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Fc receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in detection of chemical stimulus involved in sensory perception of bitter taste IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in detection of chemical stimulus involved in sensory perception of bitter taste ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epidermal growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in receptor clustering IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in receptor clustering ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of secretory IgA immunoglobulin complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of secretory IgA immunoglobulin complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of secretory IgA immunoglobulin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    polymeric immunoglobulin receptor
    Names
    poly-Ig receptor
    polymeric IgA receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429542.1NP_001416471.1  polymeric immunoglobulin receptor precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      P15083
      UniProtKB/TrEMBL
      F1M7H2
    2. NM_001429543.1NP_001416472.1  polymeric immunoglobulin receptor precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      P15083
      UniProtKB/TrEMBL
      F1M7H2
    3. NM_012723.5NP_036855.3  polymeric immunoglobulin receptor precursor

      See identical proteins and their annotated locations for NP_036855.3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      P15083
      UniProtKB/TrEMBL
      F1M7H2
      Conserved Domains (2) summary
      cd05716
      Location:357456
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:469558
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      44851001..44879143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090372.2XP_038946300.1  polymeric immunoglobulin receptor isoform X1

      Conserved Domains (3) summary
      cd00096
      Location:144146
      Ig; Ig strand A [structural motif]
      cd05716
      Location:477572
      IgV_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins
      cl11960
      Location:144237
      Ig; Immunoglobulin domain
    2. XM_039090371.2XP_038946299.1  polymeric immunoglobulin receptor isoform X1

      Related
      ENSRNOP00000073562.2, ENSRNOT00000088449.3
      Conserved Domains (3) summary
      cd00096
      Location:144146
      Ig; Ig strand A [structural motif]
      cd05716
      Location:477572
      IgV_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins
      cl11960
      Location:144237
      Ig; Immunoglobulin domain
    3. XM_063272039.1XP_063128109.1  polymeric immunoglobulin receptor isoform X1

      UniProtKB/TrEMBL
      A0A0G2K5U5, F1M7H2