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    Plcb1 phospholipase C beta 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24654, updated on 27-Nov-2024

    Summary

    Official Symbol
    Plcb1provided by RGD
    Official Full Name
    phospholipase C beta 1provided by RGD
    Primary source
    RGD:3344
    See related
    EnsemblRapid:ENSRNOG00000004810 AllianceGenome:RGD:3344
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PLC'1; Phosphb; PLCbeta1; RATPHOSPHB
    Summary
    Enables calcium ion binding activity; identical protein binding activity; and phosphatidylinositol phospholipase C activity. Involved in several processes, including cellular response to glyceraldehyde; cellular response to ionomycin; and learning or memory. Predicted to be located in chromatin and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in several cellular components, including GABA-ergic synapse; nuclear speck; and postsynaptic cytosol. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in Alzheimer's disease; developmental and epileptic encephalopathy 12; and myelodysplastic syndrome. Orthologous to human PLCB1 (phospholipase C beta 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 223.6), Adrenal (RPKM 196.4) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Plcb1 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (142512765..143224042)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (122059988..122772896)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (127721244..128419565)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L6, pseudogene 12 Neighboring gene thioredoxin-related transmembrane protein 4 Neighboring gene rhotekin, pseudogene 1 Neighboring gene uncharacterized LOC120101919 Neighboring gene NSA2 ribosome biogenesis factor, pseudogene 5 Neighboring gene mRNA turnover protein 4 homolog Neighboring gene uncharacterized LOC120101678

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables lamin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables lamin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol phospholipase C activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol phospholipase C activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled acetylcholine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G2/M transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of meiosis involved in egg activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in activation of meiosis involved in egg activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of meiosis involved in egg activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to fluoride IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to glyceraldehyde IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to ionomycin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to vasopressin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cerebral cortex development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cerebral cortex development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cerebral cortex development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glutamate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glutamate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glutamate receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in inositol trisphosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin-like growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin-like growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in interleukin-1-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in interleukin-1-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in interleukin-12-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in interleukin-12-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in interleukin-15-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in interleukin-15-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ion channel modulating, G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ion channel modulating, G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in learning IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in ligand-gated ion channel signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ligand-gated ion channel signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in memory IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in memory IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in memory IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of monocyte extravasation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of monocyte extravasation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of monocyte extravasation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phosphatidylinositol catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylinositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylinositol metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in phosphatidylinositol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of CD24 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of CD24 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of CD24 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of G1/S transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of acrosome reaction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of acrosome reaction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of developmental growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of developmental growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of developmental growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-12 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-12 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-12 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of myoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of myoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in postsynaptic modulation of chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in postsynaptic modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of establishment of endothelial barrier IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of fertilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of fertilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of retrograde trans-synaptic signaling by endocanabinoid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of retrograde trans-synaptic signaling by endocanabinoid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to monosaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to peptide hormone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in postsynaptic cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
    Names
    PLC-154
    PLC-I
    PLC-beta-1
    Phospholipase C-beta1
    phosphoinositide phospholipase C
    phosphoinositide phospholipase C-beta-1
    phospholipase C, beta 1 (phosphoinositide-specific)
    phospholipase C-I
    NP_001071109.1
    XP_017446956.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077641.2NP_001071109.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

      See identical proteins and their annotated locations for NP_001071109.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P10687
      UniProtKB/TrEMBL
      A6HQI6
      Related
      ENSRNOP00000006389.7, ENSRNOT00000006389.8
      Conserved Domains (7) summary
      cd00275
      Location:677796
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:316643
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02952
      Location:216784
      PLN02952; phosphoinositide phospholipase C
      cd13361
      Location:22148
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam06631
      Location:903939
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:10031172
      PLC-beta_C; PLC-beta C terminal
      pfam09279
      Location:224314
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      142512765..143224042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591467.3XP_017446956.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A2P4, R9PXY3
      Related
      ENSRNOP00000042533.5, ENSRNOT00000051184.7