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    Nrdc nardilysin convertase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25499, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nrdcprovided by RGD
    Official Full Name
    nardilysin convertaseprovided by RGD
    Primary source
    RGD:3210
    See related
    EnsemblRapid:ENSRNOG00000007111 AllianceGenome:RGD:3210
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nrd1
    Summary
    Enables peptidase activity. Predicted to be involved in negative regulation of cold-induced thermogenesis; regulation of nervous system development; and regulation of proteolysis. Predicted to be located in dendrite. Predicted to be active in mitochondrial matrix. Orthologous to human NRDC (nardilysin convertase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 350.4), Kidney (RPKM 265.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nrdc in Genome Data Viewer
    Location:
    5q34
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (128983395..129047578)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (123755807..123818910)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (128629949..128694209)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene RAB3B, member RAS oncogene family Neighboring gene uncharacterized LOC134486965 Neighboring gene RNA, U6 small nuclear 304 Neighboring gene microRNA 761 Neighboring gene oxysterol binding protein-like 9 Neighboring gene uncharacterized LOC120103121 Neighboring gene uncharacterized LOC134486963

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. N-arginine dibasic convertase, a metalloendopeptidase as a prototype of a class of processing enzymes. Pierotti AR, et al. Proc Natl Acad Sci U S A, 1994 Jun 21. PMID 8016118, Free PMC Article
    2. N-arginine dibasic convertase (NRD convertase): a newcomer to the family of processing endopeptidases. An overview. Chesneau V, et al. Biochimie, 1994. PMID 7819328
    3. Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family. Hospital V, et al. Biochem J, 1997 Nov 1. PMID 9581555, Free PMC Article
    4. Critical roles of nardilysin in the maintenance of body temperature homoeostasis. Hiraoka Y, et al. Nat Commun, 2014. PMID 24492630, Free PMC Article
    5. Interaction of the brain-specific protein p42IP4/centaurin-alpha1 with the peptidase nardilysin is regulated by the cognate ligands of p42IP4, PtdIns(3,4,5)P3 and Ins(1,3,4,5)P4, with stereospecificity. Stricker R, et al. J Neurochem, 2006 Jul. PMID 16805830

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of axonogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of membrane protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of membrane protein ectodomain proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of myelination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nardilysin
    Names
    N-arginine dibasic convertase 1
    NRD convertase
    NRD-C
    nardilysin 1 (N-arginine dibasic convertase)
    nardilysin, N-arginine dibasic convertase 1
    nardilysin, N-arginine dibasic convertase, NRD convertase 1
    NP_037125.1
    XP_006238561.1
    XP_038965232.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012993.2 → NP_037125.1  nardilysin precursor

      See identical proteins and their annotated locations for NP_037125.1

      Status: PROVISIONAL

      Source sequence(s)
      L27124
      UniProtKB/Swiss-Prot
      O35836, P47245
      UniProtKB/TrEMBL
      A6JYX3, G3V700
      Related
      ENSRNOP00000101780.1, ENSRNOT00000161635.1
      Conserved Domains (4) summary
      COG1025
      Location:222 → 1100
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
      pfam00675
      Location:210 → 348
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:373 → 559
      Peptidase_M16_C; Peptidase M16 inactive domain
      pfam16187
      Location:564 → 845
      Peptidase_M16_M; Middle or third domain of peptidase_M16

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      128983395..129047578
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238499.5 → XP_006238561.1  nardilysin isoform X1

      UniProtKB/TrEMBL
      A0A8I6GH79, D3ZQ59
      Related
      ENSRNOP00000010462.3, ENSRNOT00000010462.9
      Conserved Domains (4) summary
      COG1025
      Location:290 → 1168
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
      pfam00675
      Location:290 → 416
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:441 → 627
      Peptidase_M16_C; Peptidase M16 inactive domain
      pfam16187
      Location:632 → 913
      Peptidase_M16_M; Middle or third domain of peptidase_M16

    2. XM_039109304.2 → XP_038965232.2  nardilysin isoform X2

      UniProtKB/TrEMBL
      A6JYX3, G3V700
      Related
      ENSRNOP00000010440.5, ENSRNOT00000010440.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47245.1 GenPept UniProtKB/Swiss-Prot:P47245

    Gene LinkOut

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