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    Gnb3 G protein subunit beta 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60449, updated on 27-Nov-2024

    Summary

    Official Symbol
    Gnb3provided by RGD
    Official Full Name
    G protein subunit beta 3provided by RGD
    Primary source
    RGD:708344
    See related
    EnsemblRapid:ENSRNOG00000015541 AllianceGenome:RGD:708344
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hg2d
    Summary
    Enables spectrin binding activity. Predicted to be involved in several processes, including cell volume homeostasis; regulation of fat cell differentiation; and regulation of lipid metabolic process. Located in cell body. Human ortholog(s) of this gene implicated in artery disease (multiple); congenital stationary night blindness 1H; depressive disorder; familial hyperlipidemia; and type 2 diabetes mellitus. Orthologous to human GNB3 (G protein subunit beta 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 131.2), Thymus (RPKM 14.0) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Gnb3 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159325741..159331443, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157639468..157645171, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157352558..157359237, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene splA/ryanodine receptor domain and SOCS box containing 2 Neighboring gene triosephosphate isomerase 1 Neighboring gene ubiquitin specific peptidase 5 Neighboring gene cell division cycle associated 3 Neighboring gene prolyl 3-hydroxylase 3 Neighboring gene uncharacterized LOC120102385 Neighboring gene G protein-coupled receptor 162

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC105437

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor complex adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables spectrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of heterotrimeric G-protein complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
    Names
    G protein beta-subunit
    guanine nucleotide binding protein (G protein), beta 3
    guanine nucleotide binding protein (G protein), beta polypeptide 3
    guanine nucleotide binding protein, beta 3
    guanine nucleotide-binding protein, beta-3 subunit
    heterotrimeric guanine nucleotide-binding protein 2d
    transducin beta chain 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021858.3NP_068630.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

      See identical proteins and their annotated locations for NP_068630.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086422
      UniProtKB/Swiss-Prot
      P52287
      UniProtKB/TrEMBL
      A6ILM1, Q45QL4
      Related
      ENSRNOP00000021480.3, ENSRNOT00000021481.6
      Conserved Domains (2) summary
      cd00200
      Location:48340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5895
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      159325741..159331443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)