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    Tac3 tachykinin precursor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29191, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tac3provided by RGD
    Official Full Name
    tachykinin precursor 3provided by RGD
    Primary source
    RGD:3809
    See related
    EnsemblRapid:ENSRNOG00000004229 AllianceGenome:RGD:3809
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tac2
    Summary
    Predicted to enable neuromedin K receptor binding activity and substance K receptor binding activity. Involved in positive regulation of blood pressure. Predicted to be located in extracellular space. Biomarker of hypertension. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 10 with or without anosmia. Orthologous to human TAC3 (tachykinin precursor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 38.6), Brain (RPKM 32.1) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tac3 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (65447817..65454427)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (63562552..63569170)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (71023976..71030582)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479888 Neighboring gene nuclear envelope integral membrane protein 1 Neighboring gene myosin IA Neighboring gene zinc finger and BTB domain containing 39 Neighboring gene G protein-coupled receptor 182

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables neuromedin K receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables substance K receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of blood pressure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tachykinin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tachykinin-3
    Names
    neurokinin B
    tachykinin 2
    tachykinin 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019162.2NP_062035.1  tachykinin-3 precursor

      See identical proteins and their annotated locations for NP_062035.1

      Status: PROVISIONAL

      Source sequence(s)
      M16410
      UniProtKB/Swiss-Prot
      P08435
      Related
      ENSRNOP00000005679.1, ENSRNOT00000005679.4
      Conserved Domains (1) summary
      pfam03823
      Location:135
      Neurokinin_B; Neurokinin B

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      65447817..65454427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263110.1XP_063119180.1  tachykinin-3 isoform X1

      UniProtKB/TrEMBL
      A6HQX0, G3V6J3