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    Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286953, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cyp2b3provided by RGD
    Official Full Name
    cytochrome P450, family 2, subfamily b, polypeptide 3provided by RGD
    Primary source
    RGD:628627
    See related
    EnsemblRapid:ENSRNOG00000084200 AllianceGenome:RGD:628627
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cyp2b6; CYPIIB3
    Summary
    Predicted to enable heme binding activity and monooxygenase activity. Involved in response to organic cyclic compound and response to xenobiotic stimulus. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; drug dependence (multiple); human immunodeficiency virus infectious disease; neonatal abstinence syndrome; and nicotine dependence. Orthologous to human CYP2B6 (cytochrome P450 family 2 subfamily B member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 2099.3) See more
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    Genomic context

    See Cyp2b3 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (90780468..90859852)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (81652762..81732153)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (83163103..83236615)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene protein NYNRIN-like Neighboring gene cytochrome P450, family 2, subfamily b, polypeptide 2 Neighboring gene eukaryotic translation initiation factor 4, gamma 2, pseudogene 2 Neighboring gene cytochrome P450 2B9-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables anandamide 11,12 epoxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables anandamide 14,15 epoxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables anandamide 8,9 epoxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables arachidonate epoxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables estrogen 2-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables monooxygenase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables testosterone 16-alpha-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables testosterone 16-beta-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in epoxygenase P450 pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ketone metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    cytochrome P450 2B3
    Names
    cytochrome P450 2B3-like
    cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6
    cytochrome P450IIB3
    NP_775416.1
    XP_038958625.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173294.3NP_775416.1  cytochrome P450 2B3 precursor

      See identical proteins and their annotated locations for NP_775416.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      A1L121, P13107, Q3B8R5, Q64585
      UniProtKB/TrEMBL
      A6J997
      Related
      ENSRNOP00000045196.6, ENSRNOT00000047540.7
      Conserved Domains (1) summary
      pfam00067
      Location:42488
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      90780468..90859852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102697.2XP_038958625.1  cytochrome P450 2B3 isoform X1

      UniProtKB/TrEMBL
      Q6LCX2
      Conserved Domains (1) summary
      cl41757
      Location:62277
      cytochrome_P450; cytochrome P450 (CYP) superfamily