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    Vamp1 vesicle-associated membrane protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25624, updated on 9-Dec-2024

    Summary

    Official Symbol
    Vamp1provided by RGD
    Official Full Name
    vesicle-associated membrane protein 1provided by RGD
    Primary source
    RGD:3948
    See related
    EnsemblRapid:ENSRNOG00000019219 AllianceGenome:RGD:3948
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Syb1
    Summary
    Predicted to enable SNAP receptor activity and syntaxin binding activity. Predicted to be involved in SNARE complex assembly; regulation of synaptic vesicle fusion to presynaptic active zone membrane; and synaptic vesicle priming. Located in terminal bouton. Is active in presynapse. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome and spastic ataxia 1. Orthologous to human VAMP1 (vesicle associated membrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 443.0), Thymus (RPKM 213.7) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Vamp1 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159698894..159705582)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (158012634..158019350)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157726941..157733644)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene non-SMC condensin I complex, subunit D2 Neighboring gene small Cajal body-specific RNA 10 Neighboring gene mitochondrial ribosomal protein L51 Neighboring gene TAP binding protein-like Neighboring gene uncharacterized LOC120102390 Neighboring gene CD27 molecule

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in SNARE complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in SNARE complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular protein transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of synaptic vesicle fusion to presynaptic active zone membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic vesicle priming ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT located_in azurophil granule membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    NOT located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in presynapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in specific granule membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in terminal bouton HDA PubMed 
    located_in tertiary granule membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    vesicle-associated membrane protein 1
    Names
    VAMP-1
    synaptobrevin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013090.2NP_037222.2  vesicle-associated membrane protein 1

      See identical proteins and their annotated locations for NP_037222.2

      Status: VALIDATED

      Source sequence(s)
      AI059682, BC092206, CB582258, CO567426
      UniProtKB/Swiss-Prot
      A6YSN3, O09025, Q56A22, Q63666, Q8CH14
      UniProtKB/TrEMBL
      A6ILS9, A6ILT1
      Related
      ENSRNOP00000025081.7, ENSRNOT00000025081.7
      Conserved Domains (2) summary
      cd15870
      Location:3294
      R-SNARE_VAMP2; SNARE motif of VAMP2
      pfam00957
      Location:30106
      Synaptobrevin; Synaptobrevin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      159698894..159705582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)