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    Gria4 glutamate ionotropic receptor AMPA type subunit 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29629, updated on 3-Dec-2024

    Summary

    Official Symbol
    Gria4provided by RGD
    Official Full Name
    glutamate ionotropic receptor AMPA type subunit 4provided by RGD
    Primary source
    RGD:61863
    See related
    EnsemblRapid:ENSRNOG00000006957 AllianceGenome:RGD:61863
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GluA4; GluR4; GluR-D
    Summary
    Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward (RPKM 345.6) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gria4 in Genome Data Viewer
    Location:
    8q11
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (9845421..10320021, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (1562118..2035035, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (1548145..2045874, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 431 like, pseudogene 4 Neighboring gene Myb/SANT DNA binding domain containing 4 with coiled-coils Neighboring gene uncharacterized LOC120094073 Neighboring gene uncharacterized LOC134480139 Neighboring gene phosphoglycerate kinase 1, pseudogene 4 Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 35

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables AMPA glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables AMPA glutamate receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMPA glutamate receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables AMPA glutamate receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables AMPA glutamate receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables glutamate-gated receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of AMPA glutamate receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of AMPA glutamate receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of AMPA glutamate receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ionotropic glutamate receptor complex TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of kainate selective glutamate receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynaptic active zone membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    glutamate receptor 4
    Names
    AMPA-selective glutamate receptor 4
    glutamate receptor, ionotrophic, AMPA 4
    glutamate receptor, ionotropic, AMPA 4
    glutamate receptor, ionotropic, AMPA4 (alpha 4)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113184.1NP_001106655.1  glutamate receptor 4 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001106655.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate internal coding exon compared to transcript variant 1, and encodes an isoform (2, also known as flop isoform) that is the same length, but with a few amino acid differences compared to isoform 1. RNA editing (AGA->GGA) changes Arg765Gly.
      Source sequence(s)
      BC093608, BF390245, BF390683, BF413680, CB761818, CK598329, M36421, M85037
      UniProtKB/Swiss-Prot
      P19493, Q64241
      UniProtKB/TrEMBL
      A6KQJ7, G3V6W1
      Related
      ENSRNOP00000009542.6, ENSRNOT00000009542.7
      Conserved Domains (4) summary
      cd06388
      Location:28398
      PBP1_iGluR_AMPA_GluR4; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor
      cd13727
      Location:414795
      PBP2_iGluR_AMPA_GluR4; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR4 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:546825
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:39380
      ANF_receptor; Receptor family ligand binding region
    2. NM_001113185.1NP_001106656.1  glutamate receptor 4 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001106656.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) is missing several coding exons at the 3' end, and contains a novel 3' terminal exon compared to transcript variant 1. This results in a shorter isoform (3) with a different C-terminus compared to isoform 1.
      Source sequence(s)
      BC093608, CB761818, DV726151
      UniProtKB/TrEMBL
      A0A8I5ZUN6, Q566D4
      Related
      ENSRNOP00000068876.1, ENSRNOT00000078765.3
      Conserved Domains (2) summary
      cd06388
      Location:28398
      PBP1_iGluR_AMPA_GluR4; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor
      pfam01094
      Location:39380
      ANF_receptor; Receptor family ligand binding region
    3. NM_017263.2NP_058959.2  glutamate receptor 4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_058959.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1 (also known as flip isoform). RNA editing (AGA->GGA) changes Arg765Gly.
      Source sequence(s)
      BC093608, BF390245, BF390683, BF413680, CB761818, M38063, M85037
      UniProtKB/Swiss-Prot
      P19493, Q64241
      UniProtKB/TrEMBL
      A0A0G2JU28, A6KQJ6
      Related
      ENSRNOP00000068940.1, ENSRNOT00000081171.3
      Conserved Domains (4) summary
      cd06388
      Location:28398
      PBP1_iGluR_AMPA_GluR4; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor
      cd13727
      Location:414795
      PBP2_iGluR_AMPA_GluR4; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR4 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:546825
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:39380
      ANF_receptor; Receptor family ligand binding region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      9845421..10320021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265032.1XP_063121102.1  glutamate receptor 4 isoform X4

      UniProtKB/Swiss-Prot
      P19493, Q64241
    2. XM_063265033.1XP_063121103.1  glutamate receptor 4 isoform X5

      UniProtKB/Swiss-Prot
      P19493, Q64241
    3. XM_063265031.1XP_063121101.1  glutamate receptor 4 isoform X1

      UniProtKB/Swiss-Prot
      P19493, Q64241
    4. XM_017595511.3XP_017451000.1  glutamate receptor 4 isoform X2

      UniProtKB/Swiss-Prot
      P19493, Q64241
    5. XM_017595510.3XP_017450999.1  glutamate receptor 4 isoform X3

      UniProtKB/Swiss-Prot
      P19493, Q64241
    6. XM_039080969.2XP_038936897.1  glutamate receptor 4 isoform X6

      UniProtKB/Swiss-Prot
      P19493, Q64241
      Related
      ENSRNOP00000081710.2, ENSRNOT00000111725.2
      Conserved Domains (2) summary
      cd06388
      Location:28400
      PBP1_iGluR_AMPA_GluR4; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor
      cl21456
      Location:414765
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

    RNA

    1. XR_010053935.1 RNA Sequence

    2. XR_010053936.1 RNA Sequence

    3. XR_010053937.1 RNA Sequence