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    Pth1r parathyroid hormone 1 receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 56813, updated on 27-Nov-2024

    Summary

    Official Symbol
    Pth1rprovided by RGD
    Official Full Name
    parathyroid hormone 1 receptorprovided by RGD
    Primary source
    RGD:3442
    See related
    EnsemblRapid:ENSRNOG00000020948 AllianceGenome:RGD:3442
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pthr; Pthr1; PTHrel
    Summary
    Enables parathyroid hormone receptor activity and peptide hormone binding activity. Involved in G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; and positive regulation of inositol phosphate biosynthetic process. Located in apical plasma membrane; basolateral plasma membrane; and brush border membrane. Part of receptor complex. Used to study hypercalcemia. Human ortholog(s) of this gene implicated in Eiken syndrome; Jansen's metaphyseal chondrodysplasia; chondrodysplasia Blomstrand type; osteochondrodysplasia; and primary failure of tooth eruption. Orthologous to human PTH1R (parathyroid hormone 1 receptor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 243.9), Liver (RPKM 24.2) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Pth1r in Genome Data Viewer
    Location:
    8q32
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (119572295..119597405, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (110693910..110725458, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (118984531..119012803, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene neurobeachin-like 2 Neighboring gene coiled-coil domain containing 12 Neighboring gene myosin light chain 3 Neighboring gene serine protease 42

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables parathyroid hormone receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables parathyroid hormone receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables parathyroid hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables parathyroid hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide hormone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide hormone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide hormone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bone mineralization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bone resorption IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within bone resorption ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell maturation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chondrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within chondrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ossification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in osteoblast development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within osteoblast development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IC
    Inferred by Curator
    more info
    PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of inositol phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within skeletal system development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in brush border membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    parathyroid hormone/parathyroid hormone-related peptide receptor
    Names
    PTH/PTHr receptor
    PTH/PTHrP type I receptor
    PTH1 receptor
    parathyroid hormone receptor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020073.2NP_064458.1  parathyroid hormone/parathyroid hormone-related peptide receptor precursor

      See identical proteins and their annotated locations for NP_064458.1

      Status: PROVISIONAL

      Source sequence(s)
      L19475
      UniProtKB/Swiss-Prot
      P25961
      UniProtKB/TrEMBL
      A6I3G4, A6I3G5
      Related
      ENSRNOP00000080822.1, ENSRNOT00000108530.2
      Conserved Domains (3) summary
      pfam02793
      Location:105170
      HRM; Hormone receptor domain
      cd14964
      Location:186211
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:184476
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      119572295..119597405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082024.2XP_038937952.2  parathyroid hormone/parathyroid hormone-related peptide receptor isoform X1

      Related
      ENSRNOP00000094940.1, ENSRNOT00000100984.2
    2. XM_006243999.4XP_006244061.1  parathyroid hormone/parathyroid hormone-related peptide receptor isoform X2

      See identical proteins and their annotated locations for XP_006244061.1

      UniProtKB/Swiss-Prot
      P25961
      UniProtKB/TrEMBL
      A6I3G4, A6I3G5
      Related
      ENSRNOP00000028435.3, ENSRNOT00000028435.6
      Conserved Domains (3) summary
      pfam02793
      Location:105170
      HRM; Hormone receptor domain
      cd14964
      Location:186211
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:184476
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    3. XM_006244002.4XP_006244064.1  parathyroid hormone/parathyroid hormone-related peptide receptor isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZQF2
      Related
      ENSRNOP00000111934.1, ENSRNOT00000135570.1
      Conserved Domains (2) summary
      pfam00002
      Location:163434
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:84149
      HRM; Hormone receptor domain