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    Fxyd1 FXYD domain-containing ion transport regulator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58971, updated on 3-Dec-2024

    Summary

    Official Symbol
    Fxyd1provided by RGD
    Official Full Name
    FXYD domain-containing ion transport regulator 1provided by RGD
    Primary source
    RGD:69306
    See related
    EnsemblRapid:ENSRNOG00000021079 AllianceGenome:RGD:69306
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Plm
    Summary
    This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in Heart (RPKM 972.9), Muscle (RPKM 830.7) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Fxyd1 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (95414556..95418645, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (86287163..86291478, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89484197..89488279, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene FXYD domain-containing ion transport regulator 5 Neighboring gene FXYD domain-containing ion transport regulator 7 Neighboring gene leucine-rich repeat LGI family, member 4 Neighboring gene FXYD domain-containing ion transport regulator 3 Neighboring gene uncharacterized LOC134483096

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ion channel regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sodium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sodium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of protein glutathionylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein glutathionylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of inorganic anion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of organic acid transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of sodium ion export across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of sodium ion export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of sodium ion export across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of P-type sodium:potassium-exchanging transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cardiac muscle cell contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cardiac muscle cell membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of sodium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in T-tubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in T-tubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in caveola IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercalated disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    part_of sodium:potassium-exchanging ATPase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    phospholemman
    Names
    sodium/potassium-transporting ATPase subunit FXYD1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031648.2NP_113836.2  phospholemman precursor

      See identical proteins and their annotated locations for NP_113836.2

      Status: VALIDATED

      Source sequence(s)
      CB712570, FM109156
      UniProtKB/TrEMBL
      A0A0H2UHS8, A0A8I5ZW12, A6JA55
      Related
      ENSRNOP00000028624.2, ENSRNOT00000028624.6
      Conserved Domains (1) summary
      pfam02038
      Location:2772
      ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      95414556..95418645 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088782.2XP_038944710.1  phospholemman isoform X4

      Conserved Domains (1) summary
      cl40453
      Location:63101
      FXYD; phenylalanine-X-tyrosine-aspartate (FXYD) family
    2. XM_063272192.1XP_063128262.1  phospholemman isoform X6

    3. XM_017589631.3XP_017445120.1  phospholemman isoform X5

      UniProtKB/Swiss-Prot
      O08589
      UniProtKB/TrEMBL
      A0A8I5ZW12, A6JA62
      Conserved Domains (1) summary
      pfam02038
      Location:2469
      ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family
    4. XM_039088778.2XP_038944706.1  phospholemman isoform X2

    5. XM_063272174.1XP_063128244.1  phospholemman isoform X1

      UniProtKB/TrEMBL
      A0A8I6G4X1
    6. XM_017589629.3XP_017445118.1  phospholemman isoform X1

      UniProtKB/TrEMBL
      A0A8I6G4X1
    7. XM_063272185.1XP_063128255.1  phospholemman isoform X5

      UniProtKB/Swiss-Prot
      O08589
      UniProtKB/TrEMBL
      A0A8I5ZW12, A6JA62
    8. XM_006228839.5XP_006228901.1  phospholemman isoform X5

      See identical proteins and their annotated locations for XP_006228901.1

      UniProtKB/Swiss-Prot
      O08589
      UniProtKB/TrEMBL
      A0A8I5ZW12, A6JA62
      Related
      ENSRNOP00000083421.2, ENSRNOT00000102674.2
      Conserved Domains (1) summary
      pfam02038
      Location:2469
      ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family
    9. XM_017589630.3XP_017445119.1  phospholemman isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZW12, A6JA56
      Conserved Domains (1) summary
      pfam02038
      Location:4691
      ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family
    10. XM_063272182.1XP_063128252.1  phospholemman isoform X5

      UniProtKB/Swiss-Prot
      O08589
      UniProtKB/TrEMBL
      A0A8I5ZW12, A6JA62