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    Rpl6 ribosomal protein L6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117042, updated on 27-Nov-2024

    Summary

    Official Symbol
    Rpl6provided by RGD
    Official Full Name
    ribosomal protein L6provided by RGD
    Primary source
    RGD:619826
    See related
    EnsemblRapid:ENSRNOG00000025936 AllianceGenome:RGD:619826
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables 5.8S rRNA binding activity; mRNA binding activity; and tRNA binding activity. Predicted to be involved in cytoplasmic translation. Located in A band. Part of cytosolic large ribosomal subunit. Orthologous to human RPL6 (ribosomal protein L6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 3663.1), Thymus (RPKM 3203.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rpl6 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (41008142..41012756, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (35347493..35352011, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (40877578..40882032, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S20-like Neighboring gene HECT domain E3 ubiquitin protein ligase 4 Neighboring gene TRAF type zinc finger domain containing 1 Neighboring gene small nucleolar RNA SNORA42/SNORA80 family Neighboring gene protein tyrosine phosphatase, non-receptor type 11 Neighboring gene uncharacterized LOC134481334

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC93267

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 5.8S rRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    enables tRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytoplasmic translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in A band IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic side of rough endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in rough endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    large ribosomal subunit protein eL6
    Names
    60S ribosomal protein L6
    neoplasm-related protein C140

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053971.3NP_446423.2  large ribosomal subunit protein eL6

      See identical proteins and their annotated locations for NP_446423.2

      Status: PROVISIONAL

      Source sequence(s)
      BC097295
      UniProtKB/Swiss-Prot
      P21533, Q4QRA9, Q64624, Q68G26
      UniProtKB/TrEMBL
      A6J1G1, Q6P790
      Conserved Domains (2) summary
      cd13156
      Location:146298
      KOW_RPL6; KOW motif of Ribosomal Protein L6
      pfam03868
      Location:51105
      Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      41008142..41012756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249378.5XP_006249440.1  large ribosomal subunit protein eL6 isoform X2

      See identical proteins and their annotated locations for XP_006249440.1

      UniProtKB/Swiss-Prot
      P21533, Q4QRA9, Q64624, Q68G26
      UniProtKB/TrEMBL
      A6J1G1, Q6P790
      Conserved Domains (2) summary
      cd13156
      Location:146298
      KOW_RPL6; KOW motif of Ribosomal Protein L6
      pfam03868
      Location:51105
      Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain
    2. XM_039089033.2XP_038944961.1  large ribosomal subunit protein eL6 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QIW0
      Related
      ENSRNOP00000038065.7, ENSRNOT00000034951.7
      Conserved Domains (2) summary
      cd13156
      Location:153305
      KOW_RPL6; KOW motif of Ribosomal Protein L6
      pfam03868
      Location:58112
      Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain
    3. XM_039089034.2XP_038944962.1  large ribosomal subunit protein eL6 isoform X2

      UniProtKB/Swiss-Prot
      P21533, Q4QRA9, Q64624, Q68G26
      UniProtKB/TrEMBL
      A6J1G1, Q6P790
      Conserved Domains (2) summary
      cd13156
      Location:146298
      KOW_RPL6; KOW motif of Ribosomal Protein L6
      pfam03868
      Location:51105
      Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain