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    Cs citrate synthase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170587, updated on 9-Dec-2024

    Summary

    Official Symbol
    Csprovided by RGD
    Official Full Name
    citrate synthaseprovided by RGD
    Primary source
    RGD:620330
    See related
    EnsemblRapid:ENSRNOG00000023520 AllianceGenome:RGD:620330
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables citrate (Si)-synthase activity. Involved in several processes, including acetyl-CoA metabolic process; carboxylic acid metabolic process; and tricarboxylic acid cycle. Located in mitochondrion. Used to study congestive heart failure; hyperthyroidism; hypothyroidism; limb ischemia; and myocardial infarction. Biomarker of bipolar disorder and congestive heart failure. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and hypertrophic cardiomyopathy. Orthologous to human CS (citrate synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 2316.4), Muscle (RPKM 1572.8) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    7q11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1348389..1374624)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (758074..791421)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (2752680..2778963)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene poly(A) specific ribonuclease subunit PAN2 Neighboring gene canopy FGF signaling regulator 2 Neighboring gene coenzyme Q10A Neighboring gene ankyrin repeat domain 52 Neighboring gene solute carrier family 39 member 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acyltransferase activity, acyl groups converted into alkyl on transfer ISO
    Inferred from Sequence Orthology
    more info
     
    enables citrate (Si)-synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables citrate (Si)-synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables citrate (Si)-synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables citrate (Si)-synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables citrate (Si)-synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables citrate synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in acetyl-CoA metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in carbohydrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in carbohydrate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in citrate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in citrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in heart development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in oxaloacetate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tricarboxylic acid cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    citrate synthase, mitochondrial
    Names
    citrate (Si)-synthase
    NP_570111.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130755.1NP_570111.1  citrate synthase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_570111.1

      Status: PROVISIONAL

      Source sequence(s)
      AF461496
      UniProtKB/Swiss-Prot
      Q8VHF5
      UniProtKB/TrEMBL
      G3V936
      Related
      ENSRNOP00000034921.5, ENSRNOT00000033726.7
      Conserved Domains (2) summary
      cd06105
      Location:33459
      ScCit1-2_like; Saccharomyces cerevisiae (Sc) citrate synthases Cit1-2_like. Citrate synthases (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or ...
      PLN02456
      Location:29454
      PLN02456; citrate synthase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      1348389..1374624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)