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    Chmp1a charged multivesicular body protein 1A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365024, updated on 9-Dec-2024

    Summary

    Official Symbol
    Chmp1aprovided by RGD
    Official Full Name
    charged multivesicular body protein 1Aprovided by RGD
    Primary source
    RGD:1311083
    See related
    EnsemblRapid:ENSRNOG00000016001 AllianceGenome:RGD:1311083
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pcoln3
    Summary
    Predicted to enable protein domain specific binding activity and protein homodimerization activity. Predicted to be involved in several processes, including midbody abscission; regulation of cell cycle process; and vacuolar transport. Predicted to act upstream of or within mitotic chromosome condensation and negative regulation of gene expression. Predicted to be located in several cellular components, including bounding membrane of organelle; microtubule cytoskeleton; and nuclear lumen. Predicted to be part of ESCRT III complex and nuclear pore. Predicted to be active in multivesicular body. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 8. Orthologous to human CHMP1A (charged multivesicular body protein 1A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 321.9), Kidney (RPKM 301.6) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Chmp1a in Genome Data Viewer
    Location:
    19q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (68146672..68154952, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (51238153..51246433, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (56001724..56010004, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene sulfotransferase family 5A, member 1 Neighboring gene uncharacterized LOC120098589 Neighboring gene dipeptidase 1 Neighboring gene spermatogenesis associated 33 Neighboring gene cyclin-dependent kinase 10 Neighboring gene spermatogenesis associated 2-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in autophagosome maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endosome transport via multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in late endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in late endosome to vacuole transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in midbody abscission ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mitotic chromosome condensation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in multivesicular body sorting pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear membrane reassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleus organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in plasma membrane repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in viral budding from plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in viral budding via host ESCRT complex ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of ESCRT III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in amphisome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in autophagosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in condensed nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endomembrane system ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in multivesicular body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in multivesicular body membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    charged multivesicular body protein 1a
    Names
    chromatin modifying protein 1A
    procollagen (type III) N-endopeptidase

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083313.1NP_001076782.1  charged multivesicular body protein 1a

      Status: VALIDATED

      Source sequence(s)
      BM386466, CB691666, CK358527, CO559393, CX570446
      UniProtKB/TrEMBL
      D4AE79
      Related
      ENSRNOP00000021475.5, ENSRNOT00000021483.6
      Conserved Domains (1) summary
      cl21588
      Location:12195
      Snf7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      68146672..68154952 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)