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    Klhl22 kelch-like family member 22 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303792, updated on 9-Dec-2024

    Summary

    Official Symbol
    Klhl22provided by RGD
    Official Full Name
    kelch-like family member 22provided by RGD
    Primary source
    RGD:1306288
    See related
    EnsemblRapid:ENSRNOG00000001878 AllianceGenome:RGD:1306288
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306288
    Summary
    Predicted to enable 14-3-3 protein binding activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including cellular response to L-leucine; mitotic spindle assembly checkpoint signaling; and positive regulation of TORC1 signaling. Predicted to be located in centrosome; intercellular bridge; and lysosome. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytosol; mitotic spindle; and polar microtubule. Predicted to colocalize with nucleus. Orthologous to human KLHL22 (kelch like family member 22). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 120.8), Brain (RPKM 108.0) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Klhl22 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96695168..96736079, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (83190891..83231746, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (87646489..87718808)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene protein FAM246A-like Neighboring gene scavenger receptor class F, member 2 Neighboring gene large ribosomal subunit protein eL31-like Neighboring gene ribosomal protein S15, pseudogene 13 Neighboring gene mediator complex subunit 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to L-leucine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to L-leucine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to amino acid stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to amino acid stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic sister chromatid segregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic sister chromatid segregation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic spindle assembly checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic spindle assembly checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell mediated immune response to tumor cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of TORC1 signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of TORC1 signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein monoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein monoubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein monoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Cul3-RING ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Cul3-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in polar microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in polar microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in polar microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    kelch-like protein 22
    Names
    kelch-like 22

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107079.1NP_001100549.1  kelch-like protein 22

      Status: PROVISIONAL

      Source sequence(s)
      CH473999
      UniProtKB/Swiss-Prot
      D3ZZC3, D4A9W5
      UniProtKB/TrEMBL
      A0A0G2KA06
      Related
      ENSRNOP00000112391.1, ENSRNOT00000166570.1
      Conserved Domains (4) summary
      PHA03098
      Location:52592
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:340385
      Kelch; KELCH repeat [structural motif]
      cd18461
      Location:147250
      BACK_KLHL22; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22)
      cl38908
      Location:27151
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      96695168..96736079 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270457.1XP_063126527.1  kelch-like protein 22 isoform X3

      UniProtKB/TrEMBL
      A0A0G2KA06
    2. XM_006248700.5XP_006248762.1  kelch-like protein 22 isoform X2

      UniProtKB/TrEMBL
      A0A0G2KA06
      Conserved Domains (6) summary
      smart00612
      Location:631677
      Kelch; Kelch domain
      smart00875
      Location:239342
      BACK; BTB And C-terminal Kelch
      PHA03098
      Location:138678
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:426471
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:131229
      BTB; BTB/POZ domain
      pfam01344
      Location:476519
      Kelch_1; Kelch motif
    3. XM_006248699.5XP_006248761.1  kelch-like protein 22 isoform X1

      UniProtKB/TrEMBL
      A0A0G2KA06, A0A8L2QUL2
      Related
      ENSRNOP00000063573.2, ENSRNOT00000068711.4
      Conserved Domains (6) summary
      smart00612
      Location:631677
      Kelch; Kelch domain
      smart00875
      Location:239342
      BACK; BTB And C-terminal Kelch
      PHA03098
      Location:138678
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:426471
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:131229
      BTB; BTB/POZ domain
      pfam01344
      Location:476519
      Kelch_1; Kelch motif
    4. XM_063270458.1XP_063126528.1  kelch-like protein 22 isoform X4