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    Pkp4 plakophilin 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295625, updated on 3-Dec-2024

    Summary

    Official Symbol
    Pkp4provided by RGD
    Official Full Name
    plakophilin 4provided by RGD
    Primary source
    RGD:1307840
    See related
    EnsemblRapid:ENSRNOG00000005504 AllianceGenome:RGD:1307840
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cadherin binding activity. Predicted to be involved in several processes, including cell-cell junction assembly; positive regulation of GTPase activity; and positive regulation of cytokinesis. Predicted to be located in several cellular components, including cell-cell contact zone; postsynaptic density; and spindle. Predicted to be active in several cellular components, including adherens junction; nucleus; and plasma membrane. Orthologous to human PKP4 (plakophilin 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 372.4), Kidney (RPKM 338.6) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pkp4 in Genome Data Viewer
    Location:
    3q21
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (64040995..64244586)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (43632364..43835834)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (45211097..45414524)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uridine phosphorylase 2 Neighboring gene coiled-coil domain containing 148 Neighboring gene basic proline-rich protein-like Neighboring gene dynein light chain roadblock-type 1 pseudogene Neighboring gene ribosomal protein S14, pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-cell junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell contact zone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in desmosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle midzone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427440.1NP_001414369.1  plakophilin-4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZTQ8, A0A8I6A880

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      64040995..64244586
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106305.2XP_038962233.1  plakophilin-4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      PLN03209
      Location:236393
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:634675
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:8791000
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:561586
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:590629
      Arm; Armadillo/beta-catenin-like repeat
    2. XM_039106316.2XP_038962244.1  plakophilin-4 isoform X13

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      PLN03209
      Location:236393
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:896931
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:8791000
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:561586
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:590629
      Arm; Armadillo/beta-catenin-like repeat
    3. XM_039106310.2XP_038962238.1  plakophilin-4 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      PLN03209
      Location:236393
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:618659
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:863984
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:545570
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:574613
      Arm; Armadillo/beta-catenin-like repeat
    4. XM_063283257.1XP_063139327.1  plakophilin-4 isoform X16

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
    5. XM_039106307.2XP_038962235.1  plakophilin-4 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      PLN03209
      Location:236393
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:633674
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:878999
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:560585
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:589628
      Arm; Armadillo/beta-catenin-like repeat
    6. XM_063283255.1XP_063139325.1  plakophilin-4 isoform X14

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
    7. XM_039106311.2XP_038962239.1  plakophilin-4 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      PLN03209
      Location:236393
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:617658
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:862983
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:544569
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:573612
      Arm; Armadillo/beta-catenin-like repeat
    8. XM_039106308.2XP_038962236.1  plakophilin-4 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      PLN03209
      Location:234391
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:632673
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:877998
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:559584
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:588627
      Arm; Armadillo/beta-catenin-like repeat
    9. XM_063283252.1XP_063139322.1  plakophilin-4 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
    10. XM_039106309.2XP_038962237.1  plakophilin-4 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      smart00185
      Location:618659
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:863984
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:545570
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:574613
      Arm; Armadillo/beta-catenin-like repeat
      pfam03154
      Location:72382
      Atrophin-1; Atrophin-1 family
    11. XM_063283256.1XP_063139326.1  plakophilin-4 isoform X15

      UniProtKB/TrEMBL
      A0A8I5ZTQ8, A0A8I6A222
    12. XM_063283258.1XP_063139328.1  plakophilin-4 isoform X17

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
    13. XM_063283251.1XP_063139321.1  plakophilin-4 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
    14. XM_017592152.3XP_017447641.1  plakophilin-4 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
    15. XM_039106317.2XP_038962245.1  plakophilin-4 isoform X18

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      smart00185
      Location:863898
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:846967
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:528553
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:557596
      Arm; Armadillo/beta-catenin-like repeat
      pfam03154
      Location:72382
      Atrophin-1; Atrophin-1 family
    16. XM_063283253.1XP_063139323.1  plakophilin-4 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
    17. XM_039106314.2XP_038962242.1  plakophilin-4 isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Related
      ENSRNOP00000056013.5, ENSRNOT00000059246.7
      Conserved Domains (5) summary
      smart00185
      Location:862897
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:845966
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:527552
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:556595
      Arm; Armadillo/beta-catenin-like repeat
      pfam03154
      Location:72380
      Atrophin-1; Atrophin-1 family
    18. XM_063283259.1XP_063139329.1  plakophilin-4 isoform X19

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
    19. XM_039106315.2XP_038962243.1  plakophilin-4 isoform X12

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      smart00185
      Location:861896
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:844965
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:526551
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:555594
      Arm; Armadillo/beta-catenin-like repeat
      pfam03154
      Location:72380
      Atrophin-1; Atrophin-1 family
    20. XM_039106318.2XP_038962246.1  plakophilin-4 isoform X20

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      smart00185
      Location:599640
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:844965
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:526551
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:555594
      Arm; Armadillo/beta-catenin-like repeat
      pfam03154
      Location:72380
      Atrophin-1; Atrophin-1 family
    21. XM_039106321.2XP_038962249.1  plakophilin-4 isoform X21

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      PLN03209
      Location:72229
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:470511
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:715836
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:397422
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:426465
      Arm; Armadillo/beta-catenin-like repeat
    22. XM_006234216.5XP_006234278.1  plakophilin-4 isoform X1

      See identical proteins and their annotated locations for XP_006234278.1

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      PLN03209
      Location:236393
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:634675
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:8791000
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:561586
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:590629
      Arm; Armadillo/beta-catenin-like repeat
    23. XM_039106306.2XP_038962234.1  plakophilin-4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      PLN03209
      Location:236393
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:634675
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:8791000
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:561586
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:590629
      Arm; Armadillo/beta-catenin-like repeat
    24. XM_063283250.1XP_063139320.1  plakophilin-4 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
    25. XM_063283254.1XP_063139324.1  plakophilin-4 isoform X12

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
    26. XM_063283261.1XP_063139331.1  plakophilin-4 isoform X21

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
    27. XM_063283263.1XP_063139333.1  plakophilin-4 isoform X21

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
    28. XM_063283265.1XP_063139335.1  plakophilin-4 isoform X21

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
    29. XM_063283262.1XP_063139332.1  plakophilin-4 isoform X21

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
    30. XM_063283260.1XP_063139330.1  plakophilin-4 isoform X21

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
    31. XM_063283267.1XP_063139337.1  plakophilin-4 isoform X22

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
    32. XM_039106322.2XP_038962250.1  plakophilin-4 isoform X21

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      PLN03209
      Location:72229
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:470511
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:715836
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:397422
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:426465
      Arm; Armadillo/beta-catenin-like repeat
    33. XM_063283266.1XP_063139336.1  plakophilin-4 isoform X21

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
    34. XM_063283264.1XP_063139334.1  plakophilin-4 isoform X21

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
    35. XM_039106324.2XP_038962252.1  plakophilin-4 isoform X21

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      PLN03209
      Location:72229
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:470511
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:715836
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:397422
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:426465
      Arm; Armadillo/beta-catenin-like repeat
    36. XM_039106325.2XP_038962253.1  plakophilin-4 isoform X21

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      PLN03209
      Location:72229
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:470511
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:715836
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:397422
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:426465
      Arm; Armadillo/beta-catenin-like repeat

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106482.1: Suppressed sequence

      Description
      NM_001106482.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from chicken: PKP4 (GeneID:424328).