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    Pfn1 profilin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64303, updated on 27-Nov-2024

    Summary

    Official Symbol
    Pfn1provided by RGD
    Official Full Name
    profilin 1provided by RGD
    Primary source
    RGD:621825
    See related
    AllianceGenome:RGD:621825
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables phosphatidylinositol-4,5-bisphosphate binding activity and signaling receptor binding activity. Involved in several processes, including positive regulation of nucleobase-containing compound metabolic process; positive regulation of stress fiber assembly; and positive regulation of viral transcription. Is active in several cellular components, including Schaffer collateral - CA1 synapse; parallel fiber to Purkinje cell synapse; and postsynapse. Used to study membranoproliferative glomerulonephritis. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 18. Orthologous to human PFN1 (profilin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 2826.1), Spleen (RPKM 2748.0) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pfn1 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55863882..55866587, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (55365263..55367968, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (57273003..57275708, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene glycoprotein Ib platelet subunit alpha Neighboring gene solute carrier family 25 member 11 Neighboring gene ring finger protein 167 Neighboring gene enolase 3 Neighboring gene sperm associated antigen 7 Neighboring gene calmodulin binding transcription activator 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables actin monomer binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin monomer binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables adenyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables adenyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables proline-rich region binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables proline-rich region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin polymerization or depolymerization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in modification of postsynaptic actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of stress fiber assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neural tube closure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ATP-dependent activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ruffle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ruffle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of viral transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein stabilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to tetrachloromethane IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in synapse maturation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in parallel fiber to Purkinje cell synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    profilin-1
    Names
    profilin I

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022511.2NP_071956.2  profilin-1

      See identical proteins and their annotated locations for NP_071956.2

      Status: PROVISIONAL

      Source sequence(s)
      BC062405
      UniProtKB/Swiss-Prot
      P62963
      UniProtKB/TrEMBL
      A6HG86
      Conserved Domains (1) summary
      smart00392
      Location:2140
      PROF; Profilin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      55863882..55866587 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)