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    Gpx7 glutathione peroxidase 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298376, updated on 27-Nov-2024

    Summary

    Official Symbol
    Gpx7provided by RGD
    Official Full Name
    glutathione peroxidase 7provided by RGD
    Primary source
    RGD:1306999
    See related
    EnsemblRapid:ENSRNOG00000009751 AllianceGenome:RGD:1306999
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable catalase activity. Predicted to be involved in cellular oxidant detoxification and response to oxidative stress. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Barrett's adenocarcinoma and Barrett's esophagus. Orthologous to human GPX7 (glutathione peroxidase 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 170.1), Heart (RPKM 111.6) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gpx7 in Genome Data Viewer
    Location:
    5q34
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (128373881..128381866, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (123145151..123153141, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (128001766..128009610, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase assembly factor 7 Neighboring gene shisa like 2A Neighboring gene terminal uridylyl transferase 4 Neighboring gene ribosomal protein L9, pseudogene 7 Neighboring gene 40S ribosomal protein S27-like Neighboring gene small nucleolar RNA SNORA40

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables catalase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutathione peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glutathione peroxidase 7
    NP_001100143.1
    XP_038965504.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106673.1NP_001100143.1  glutathione peroxidase 7 precursor

      See identical proteins and their annotated locations for NP_001100143.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474008
      UniProtKB/TrEMBL
      A0A8I6ARN0, A6JYU9, D3ZQI1
      Related
      ENSRNOP00000013913.5, ENSRNOT00000013913.8
      Conserved Domains (1) summary
      TIGR02540
      Location:23175
      gpx7; putative glutathione peroxidase Gpx7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      128373881..128381866 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109576.2XP_038965504.1  glutathione peroxidase 7 isoform X1

      Conserved Domains (1) summary
      cl00388
      Location:23133
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold