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    Alkbh7 alkB homolog 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 679944, updated on 9-Dec-2024

    Summary

    Official Symbol
    Alkbh7provided by RGD
    Official Full Name
    alkB homolog 7provided by RGD
    Primary source
    RGD:1598126
    See related
    EnsemblRapid:ENSRNOG00000047089 AllianceGenome:RGD:1598126
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including fatty acid metabolic process; regulation of lipid storage; and regulation of mitochondrial membrane permeability involved in programmed necrotic cell death. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Orthologous to human ALKBH7 (alkB homolog 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 167.5), Kidney (RPKM 102.5) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Alkbh7 in Genome Data Viewer
    Location:
    9q11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (1925896..1928048)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (1838886..1841044)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (10045375..10047507, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene alkaline ceramidase 1 Neighboring gene caseinolytic mitochondrial matrix peptidase proteolytic subunit Neighboring gene persephin Neighboring gene general transcription factor IIF subunit 1 Neighboring gene adenylate kinase isoenzyme 5 Neighboring gene KH-type splicing regulatory protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables 2-oxoglutarate-dependent dioxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of lipid storage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitochondrial membrane permeability involved in programmed necrotic cell death ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial
    Names
    AlkB-like protein 7
    alkB, alkylation repair homolog 7
    alkylated DNA repair protein alkB homolog 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109384.1NP_001102854.1  alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial

      See identical proteins and their annotated locations for NP_001102854.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474092
      UniProtKB/TrEMBL
      A6KQT7, M0R7T2
      Related
      ENSRNOP00000065514.1, ENSRNOT00000072118.3
      Conserved Domains (1) summary
      cl21496
      Location:33200
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      1925896..1928048
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084196.2XP_038940124.1  alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7M8, A6KQT6
      Related
      ENSRNOP00000087380.1, ENSRNOT00000097182.2
      Conserved Domains (1) summary
      cl21496
      Location:73139
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily