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    Pea15 proliferation and apoptosis adaptor protein 15 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364052, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pea15provided by RGD
    Official Full Name
    proliferation and apoptosis adaptor protein 15provided by RGD
    Primary source
    RGD:1306055
    See related
    AllianceGenome:RGD:1306055
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pea15a
    Summary
    Predicted to be involved in negative regulation of D-glucose import and negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. Predicted to act upstream of or within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors. Predicted to be located in cytosol and nucleoplasm. Orthologous to human PEA15 (proliferation and apoptosis adaptor protein 15). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 513.3), Heart (RPKM 217.4) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pea15 in Genome Data Viewer
    Location:
    13q24
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (87190189..87199811, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (84657815..84667437, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (90579844..90589466, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene COPI coat complex subunit alpha Neighboring gene peroxisomal biogenesis factor 19 Neighboring gene DDB1 and CUL4 associated factor 8 Neighboring gene calsequestrin 1 Neighboring gene ATPase Na+/K+ transporting subunit alpha 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    astrocytic phosphoprotein PEA-15
    Names
    15 kDa phosphoprotein enriched in astrocytes
    phosphoprotein enriched in astrocytes 15
    phosphoprotein enriched in astrocytes 15A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013231.1NP_001013249.1  astrocytic phosphoprotein PEA-15

      See identical proteins and their annotated locations for NP_001013249.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085766
      UniProtKB/Swiss-Prot
      Q5U318, Q78ZC9
      UniProtKB/TrEMBL
      A0A8I6AA10, A6JG35
      Conserved Domains (1) summary
      cd08338
      Location:285
      DED_PEA15; Death Effector Domain of Astrocyte phosphoprotein PEA-15

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      87190189..87199811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)