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    Tra2b transformer 2 beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117259, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tra2bprovided by RGD
    Official Full Name
    transformer 2 betaprovided by RGD
    Primary source
    RGD:619886
    See related
    EnsemblRapid:ENSRNOG00000001783 AllianceGenome:RGD:619886
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sfrs10; Srsf10
    Summary
    Predicted to enable RNA binding activity; identical protein binding activity; and protein domain specific binding activity. Involved in response to reactive oxygen species. Located in perinuclear region of cytoplasm. Orthologous to human TRA2B (transformer 2 beta homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 422.3), Spleen (RPKM 311.7) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tra2b in Genome Data Viewer
    Location:
    11q23
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (92293403..92311651)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (78788880..78807252)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (82373828..82392208)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene proteasome activator subunit 3, pseudogene 4 Neighboring gene ribosomal protein L27A like 7 Neighboring gene insulin-like growth factor 2 mRNA binding protein 2 Neighboring gene uncharacterized LOC134481028 Neighboring gene SUMO specific peptidase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables pre-mRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables pre-mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cerebral cortex regionalization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cerebral cortex regionalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryonic brain development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within embryonic brain development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of RNA splicing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of alternative mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of alternative mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to reactive oxygen species IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transformer-2 protein homolog beta
    Names
    RA301
    TRA-2 beta
    TRA2-beta
    serine/arginine-rich splicing factor 10
    splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)
    transformer 2 beta homolog
    transformer-2 protein homolog B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057119.1NP_476460.1  transformer-2 protein homolog beta

      See identical proteins and their annotated locations for NP_476460.1

      Status: PROVISIONAL

      Source sequence(s)
      D49708
      UniProtKB/Swiss-Prot
      P62997
      UniProtKB/TrEMBL
      A6JS59
      Related
      ENSRNOP00000095605.2, ENSRNOT00000102904.2
      Conserved Domains (1) summary
      cd12363
      Location:117196
      RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      92293403..92311651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248536.5XP_006248598.1  transformer-2 protein homolog beta isoform X1

      See identical proteins and their annotated locations for XP_006248598.1

      Conserved Domains (1) summary
      cd12363
      Location:117196
      RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins
    2. XM_063270247.1XP_063126317.1  transformer-2 protein homolog beta isoform X2

      UniProtKB/TrEMBL
      A0A8I6B318
      Related
      ENSRNOP00000076861.2, ENSRNOT00000105364.2