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    Dbi diazepam binding inhibitor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25045, updated on 27-Nov-2024

    Summary

    Official Symbol
    Dbiprovided by RGD
    Official Full Name
    diazepam binding inhibitorprovided by RGD
    Primary source
    RGD:2490
    See related
    EnsemblRapid:ENSRNOG00000046889 AllianceGenome:RGD:2490
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ep; Odn; Ttn; Acbp; Acoabp3; RNACOABP3
    Summary
    Enables benzodiazepine receptor binding activity and fatty-acyl-CoA binding activity. Involved in several processes, including glial cell proliferation; positive regulation of release of sequestered calcium ion into cytosol; and regulation of lipid metabolic process. Acts upstream of or within regulation of GABAergic synaptic transmission. Located in contractile muscle fiber; extracellular space; and synaptic vesicle. Orthologous to human DBI (diazepam binding inhibitor, acyl-CoA binding protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 4199.0), Kidney (RPKM 2215.2) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dbi in Genome Data Viewer
    Location:
    13q11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (33794231..33802632, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (31241466..31249853, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (36147667..36156076, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481481 Neighboring gene secretin receptor Neighboring gene transmembrane protein 37 Neighboring gene similar to chromosome 2 open reading frame 76 Neighboring gene STEAP3 metalloreductase Neighboring gene complement C1q like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables benzodiazepine receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables fatty-acyl-CoA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fatty-acyl-CoA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables fatty-acyl-CoA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables long-chain fatty acyl-CoA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within behavioral fear response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to nutrient IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in conditioned place preference IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within hair follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lateral ventricle development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within learning or memory ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of fatty acid beta-oxidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein lipidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylcholine acyl-chain remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of CoA-transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of phospholipid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of release of sequestered calcium ion into cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of synaptic transmission, GABAergic IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within skin development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in steroid biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in contractile muscle fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-lipid complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    acyl-CoA-binding protein
    Names
    Diazepam binding inhibitor (GABA receptor modulator, acyl-Coenxyme A binding protein)
    GABA receptor modulator
    LRRGT00046
    diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
    diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)
    diazepam binding inhibitor, acyl-CoA binding protein
    diazepam binding inhibitor-like
    endozepine
    octadecaneuropeptide
    triakontatetraneuropeptide
    NP_114054.1
    XP_063128108.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031853.4NP_114054.1  acyl-CoA-binding protein

      See identical proteins and their annotated locations for NP_114054.1

      Status: VALIDATED

      Source sequence(s)
      BC084717, M14201
      UniProtKB/Swiss-Prot
      P11030, Q2V4X5, Q63160
      UniProtKB/TrEMBL
      A0A8L2QZ93, A6K7Y8
      Related
      ENSRNOP00000089774.2, ENSRNOT00000117885.2
      Conserved Domains (1) summary
      cd00435
      Location:286
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      33794231..33802632 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272038.1XP_063128108.1  acyl-CoA-binding protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9F5