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    Pisd phosphatidylserine decarboxylase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 681361, updated on 27-Nov-2024

    Summary

    Official Symbol
    Pisdprovided by RGD
    Official Full Name
    phosphatidylserine decarboxylaseprovided by RGD
    Primary source
    RGD:1596729
    See related
    EnsemblRapid:ENSRNOG00000018319 AllianceGenome:RGD:1596729
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylserine decarboxylase activity. Predicted to be involved in several processes, including lipid droplet formation; mitochondrial protein catabolic process; and phosphatidylethanolamine biosynthetic process. Predicted to be located in several cellular components, including Golgi apparatus; cytosol; and lipid droplet. Predicted to be active in mitochondrion. Orthologous to human PISD (phosphatidylserine decarboxylase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 62.3), Thymus (RPKM 56.4) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pisd in Genome Data Viewer
    Location:
    14q21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (82166401..82215479)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (77941927..77991021)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (83298630..83347697)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ATP synthase subunit epsilon, mitochondrial-like Neighboring gene proline rich 14-like Neighboring gene SFI1 centrin binding protein Neighboring gene uncharacterized LOC134481863 Neighboring gene eukaryotic translation initiation factor 4E nuclear import factor 1 Neighboring gene small nuclear ribonucleoprotein polypeptide G, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylserine decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylserine decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylserine decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylserine decarboxylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in lipid droplet formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid droplet formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid droplet formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitochondrial protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrial protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phosphatidylethanolamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylethanolamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylethanolamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylethanolamine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein autoprocessing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lipid droplet ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phosphatidylserine decarboxylase proenzyme, mitochondrial
    NP_001364036.1
    NP_001386579.1
    NP_001386580.1
    XP_017454997.1
    XP_038948369.1
    XP_063129690.1
    XP_063129691.1
    XP_063129692.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001377107.2NP_001364036.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      D3ZAW2
      UniProtKB/TrEMBL
      A0A8I6GLT0, A6IK76
      Related
      ENSRNOP00000068695.3, ENSRNOT00000086090.3
      Conserved Domains (1) summary
      PLN02938
      Location:81407
      PLN02938; phosphatidylserine decarboxylase
    2. NM_001399650.1NP_001386579.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A0G2JTF7
      Related
      ENSRNOP00000079457.2, ENSRNOT00000097659.2
      Conserved Domains (1) summary
      PLN02938
      Location:70373
      PLN02938; phosphatidylserine decarboxylase
    3. NM_001399651.1NP_001386580.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      82166401..82215479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017599508.3XP_017454997.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A8L2QDB1
      Related
      ENSRNOP00000095790.2, ENSRNOT00000114187.2
    2. XM_039092441.2XP_038948369.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTF7
      Conserved Domains (1) summary
      PLN02938
      Location:70373
      PLN02938; phosphatidylserine decarboxylase
    3. XM_063273621.1XP_063129691.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTF7
    4. XM_063273622.1XP_063129692.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZNJ4
    5. XM_063273620.1XP_063129690.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTF7