Fkbp4 FKBP prolyl isomerase 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fkbp4provided by RGD
Official Full Name: FKBP prolyl isomerase 4provided by RGD
Primary source: RGD:628729
See related: EnsemblRapid:ENSRNOG00000006444 AllianceGenome:RGD:628729
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: p59; FKBP-4; FKBP-52
Summary: Enables copper-dependent protein binding activity and tau protein binding activity. Involved in copper ion transport and negative regulation of microtubule polymerization. Located in several cellular components, including axonal growth cone; neuronal cell body; and perinuclear region of cytoplasm. Part of protein-containing complex. Orthologous to human FKBP4 (FKBP prolyl isomerase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 622.0), Liver (RPKM 546.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (163389464..163397918, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (161703379..161711833, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (161748993..161757447, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data demonstrate that FKBP52 associates with TRPC3 via an as-yet-undescribed binding site in the C-terminus of TRPC3 and modulates TRPC3-dependent Ca(2+) signals in a PPIase-dependent manner. This functional interaction might be crucial for limiting TRPC3-dependent signaling during chronic hypertrophic stimulation.
Title: FKBP52 regulates TRPC3-dependent Ca(2+) signals and the hypertrophic growth of cardiomyocyte cultures.
the upregulation of cochaperone FKBP52 may mediate the activation of AR through the MAPK/ERK pathway.
Title: Expression of FKBP52 in the ovaries of PCOS rats.
Data show that FKBP52, which is abundant in brain, binds directly and specifically to Tau, especially in its hyperphosphorylated form.
Title: A role for FKBP52 in Tau protein function.
FKBP52 is a component of the copper efflux machinery, and in so, may also promote neuroprotection from copper toxicity
Title: A novel role for the immunophilin FKBP52 in copper transport.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BI279823 (e-PCR)
- UniSTS:245038

RH125352 (e-PCR)
- UniSTS:162174

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity	IEA Inferred from Electronic Annotation more info
enables copper-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables nuclear glucocorticoid receptor binding	ISO Inferred from Sequence Orthology more info
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-prolyl cis-trans isomerase activity	ISO Inferred from Sequence Orthology more info
enables peptidyl-prolyl cis-trans isomerase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables tau protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in chaperone-mediated protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in chaperone-mediated protein folding	ISO Inferred from Sequence Orthology more info
involved_in chaperone-mediated protein folding	ISS Inferred from Sequence or Structural Similarity more info
involved_in copper ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo implantation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within male sex differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of microtubule polymerization or depolymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within prostate gland development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein-containing complex localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within reproductive structure development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within steroid hormone receptor complex assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axonal growth cone	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: peptidyl-prolyl cis-trans isomerase FKBP4

Names: 52 kDa FK506-binding protein; 52 kDa FKBP; 59 kDa immunophilin; FK506 binding protein 52; FK506-binding protein 4; FKBP52 protein; FKBP59; HBI; HSP-binding immunophilin; PPIase FKBP4; immunophilin FKBP52; rotamase

NP_001178792.1

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191863.1 → NP_001178792.1 peptidyl-prolyl cis-trans isomerase FKBP4

See identical proteins and their annotated locations for NP_001178792.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

A6IM14, Q8K3U8, Q9QVC8

UniProtKB/TrEMBL

A0A8I5ZLF1

Related

ENSRNOP00000008737.6, ENSRNOT00000008737.8

Conserved Domains (5) summary

sd00006
Location:274 → 301

TPR; TPR repeat [structural motif]

pfam00254
Location:43 → 134

FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

pfam00515
Location:321 → 352

TPR_1; Tetratricopeptide repeat

pfam07719
Location:354 → 386

TPR_2; Tetratricopeptide repeat

pfam13414
Location:322 → 384

TPR_11; TPR repeat