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    Dio1 iodothyronine deiodinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25430, updated on 27-Nov-2024

    Summary

    Official Symbol
    Dio1provided by RGD
    Official Full Name
    iodothyronine deiodinase 1provided by RGD
    Primary source
    RGD:2504
    See related
    EnsemblRapid:ENSRNOG00000061237 AllianceGenome:RGD:2504
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    5DI; ITDI1; TXDI1
    Summary
    The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. The activation reaction involves the conversion of the prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland, to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by 5'-deiodination. This protein is expressed predominantly in the liver and kidney and provides most of the circulating T3, which is essential for growth, differentiation and basal metabolism in vertebrates. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2016]
    Expression
    Biased expression in Kidney (RPKM 1336.0) and Liver (RPKM 709.8) See more
    Orthologs
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    Genomic context

    See Dio1 in Genome Data Viewer
    Location:
    5q34
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (127303089..127319784, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (122074285..122090983, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (126894837..126911532, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 1 Neighboring gene leucine rich repeat containing 42 Neighboring gene intraflagellar transport 25 Neighboring gene uncharacterized LOC134486960 Neighboring gene Yip1 domain family, member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC93462

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables selenium binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables thyroxine 5'-deiodinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables thyroxine 5'-deiodinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables thyroxine 5'-deiodinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables thyroxine 5'-deiodinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in amino acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in generation of precursor metabolites and energy NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in hormone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in thyroid hormone metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    type I iodothyronine deiodinase
    Names
    DIOI
    deiodinase, iodothyronine, type I
    thyroxine deiodinase, type I
    type 1 DI
    type-I 5'-deiodinase
    NP_001311139.1
    NP_067685.5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324210.1NP_001311139.1  type I iodothyronine deiodinase isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which causes a frameshift compared to variant 1. The resulting isoform (2) is shorter, with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC083557, JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P24389
    2. NM_021653.4NP_067685.5  type I iodothyronine deiodinase isoform 1

      See identical proteins and their annotated locations for NP_067685.5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC083557, JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P24389
      UniProtKB/TrEMBL
      A0A0G2JXM4
      Related
      ENSRNOP00000070330.2, ENSRNOT00000091521.3
      Conserved Domains (1) summary
      cl00388
      Location:8247
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      127303089..127319784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)