Eif2b3 eukaryotic translation initiation factor 2B subunit gamma [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eif2b3provided by RGD
Official Full Name: eukaryotic translation initiation factor 2B subunit gammaprovided by RGD
Primary source: RGD:620821
See related: EnsemblRapid:ENSRNOG00000018375 AllianceGenome:RGD:620821
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Contributes to guanyl-nucleotide exchange factor activity. Involved in several processes, including hippocampus development; response to glucose; and response to heat. Part of eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 3. Orthologous to human EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 104.0), Spleen (RPKM 70.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (135728764..135795276)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (130492167..130558692)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (135882946..135949276)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
contributes_to guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
contributes_to guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to translation factor activity, RNA binding	ISO Inferred from Sequence Orthology more info
contributes_to translation factor activity, RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
contributes_to translation initiation factor activity	ISO Inferred from Sequence Orthology more info
contributes_to translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytoplasmic translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoplasmic translational initiation	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic translational initiation	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic translational initiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in oligodendrocyte development	IEA Inferred from Electronic Annotation more info
involved_in oligodendrocyte development	ISO Inferred from Sequence Orthology more info
involved_in oligodendrocyte development	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to glucose	IDA Inferred from Direct Assay more info	PubMed
involved_in response to heat	IDA Inferred from Direct Assay more info	PubMed
involved_in response to peptide hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in translation	TAS Traceable Author Statement more info	PubMed
involved_in translational initiation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	ISO Inferred from Sequence Orthology more info
involved_in translational initiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 2B complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 2B complex	IDA Inferred from Direct Assay more info	PubMed
part_of eukaryotic translation initiation factor 2B complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 2B complex	ISO Inferred from Sequence Orthology more info
part_of eukaryotic translation initiation factor 2B complex	ISS Inferred from Sequence or Structural Similarity more info
part_of guanyl-nucleotide exchange factor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: translation initiation factor eIF2B subunit gamma

Names: eIF-2B GDP-GTP exchange factor subunit gamma; eIF2B GDP-GTP exchange factor subunit gamma; eukaryotic translation initiation factor 2B, subunit 3 (gamma, 58kD); eukaryotic translation initiation factor 2B, subunit 3 gamma; translation initiation factor eIF-2B subunit gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133609.2 → NP_598293.2 translation initiation factor eIF2B subunit gamma

See identical proteins and their annotated locations for NP_598293.2

Status: VALIDATED

Source sequence(s)

BC072507

UniProtKB/Swiss-Prot

P70541, Q6IN08

UniProtKB/TrEMBL

A0A8I6APB6, A6JZB6

Related

ENSRNOP00000024841.8, ENSRNOT00000024841.9

Conserved Domains (3) summary

cd04652
Location:357 → 437

LbH_eIF2B_gamma_C; eIF-2B gamma subunit, C-terminal Left-handed parallel beta-Helix (LbH) domain: eIF-2B is a eukaryotic translation initiator, a guanine nucleotide exchange factor (GEF) composed of five different subunits (alpha, beta, gamma, delta and epsilon). eIF2B is ...

cd04198
Location:3 → 212

eIF-2B_gamma_N; The N-terminal domain of gamma subunit of the eIF-2B is a subfamily of glycosyltransferase 2

COG1208
Location:4 → 447

GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

135728764..135795276

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006238630.4 → XP_006238692.1 translation initiation factor eIF2B subunit gamma isoform X2

See identical proteins and their annotated locations for XP_006238692.1

UniProtKB/Swiss-Prot

P70541, Q6IN08

UniProtKB/TrEMBL

A0A8I6APB6, A6JZB6

Conserved Domains (3) summary

cd04652
Location:357 → 437

LbH_eIF2B_gamma_C; eIF-2B gamma subunit, C-terminal Left-handed parallel beta-Helix (LbH) domain: eIF-2B is a eukaryotic translation initiator, a guanine nucleotide exchange factor (GEF) composed of five different subunits (alpha, beta, gamma, delta and epsilon). eIF2B is ...

cd04198
Location:3 → 212

eIF-2B_gamma_N; The N-terminal domain of gamma subunit of the eIF-2B is a subfamily of glycosyltransferase 2

COG1208
Location:4 → 447

GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]
XM_063287117.1 → XP_063143187.1 translation initiation factor eIF2B subunit gamma isoform X1

UniProtKB/TrEMBL

A0A8I5ZKY2, A0A8I6APB6

Related

ENSRNOP00000095520.2, ENSRNOT00000109617.2
XM_039109223.2 → XP_038965151.1 translation initiation factor eIF2B subunit gamma isoform X3

Conserved Domains (1) summary

cd04652
Location:142 → 222

LbH_eIF2B_gamma_C; eIF-2B gamma subunit, C-terminal Left-handed parallel beta-Helix (LbH) domain: eIF-2B is a eukaryotic translation initiator, a guanine nucleotide exchange factor (GEF) composed of five different subunits (alpha, beta, gamma, delta and epsilon). eIF2B is ...