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    B4galt1 beta-1,4-galactosyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24390, updated on 9-Dec-2024

    Summary

    Official Symbol
    B4galt1provided by RGD
    Official Full Name
    beta-1,4-galactosyltransferase 1provided by RGD
    Primary source
    RGD:620900
    See related
    EnsemblRapid:ENSRNOG00000059461 AllianceGenome:RGD:620900
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ggtb2
    Summary
    Predicted to enable several functions, including UDP-galactosyltransferase activity; manganese ion binding activity; and tubulin binding activity. Predicted to be involved in lipid metabolic process; positive regulation of circulating fibrinogen levels; and protein N-linked glycosylation. Predicted to act upstream of or within several processes, including binding activity of sperm to zona pellucida; lactose biosynthetic process; and regulation of epithelial cell proliferation. Predicted to be located in several cellular components, including Golgi trans cisterna; basolateral plasma membrane; and brush border membrane. Predicted to be part of protein-containing complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation and congenital disorder of glycosylation type IId. Orthologous to human B4GALT1 (beta-1,4-galactosyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 196.3), Lung (RPKM 140.0) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See B4galt1 in Genome Data Viewer
    Location:
    5q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (60731601..60778456, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (55935614..55982461, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (57121768..57168610, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member A1 Neighboring gene microRNA 207 Neighboring gene SMU1, DNA replication regulator and spliceosomal factor Neighboring gene uncharacterized LOC134486929 Neighboring gene serine peptidase inhibitor, Kazal type 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetyllactosamine synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables N-acetyllactosamine synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables UDP-galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables UDP-galactosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables alpha-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables beta-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lactose synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lactose synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in acute inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within acute inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in angiogenesis involved in wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within angiogenesis involved in wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in binding of sperm to zona pellucida IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within binding of sperm to zona pellucida ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in development of secondary sexual characteristics IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within development of secondary sexual characteristics ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epithelial cell development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within epithelial cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in galactose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within galactose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glycoprotein biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lactose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lactose biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lactose biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in macrophage migration IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within macrophage migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within oligosaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oligosaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oligosaccharide biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in penetration of zona pellucida IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within penetration of zona pellucida ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of circulating fibrinogen levels IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of circulating fibrinogen levels ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of circulating fibrinogen levels ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of epithelial cell proliferation involved in wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein N-linked glycosylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of acrosome reaction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of acrosome reaction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi trans cisterna IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi trans cisterna ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in desmosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in desmosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in filopodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    beta-1,4-galactosyltransferase 1
    Names
    Glycoprotein-4-beta-galactosyltransferase 2
    N-acetyllactosamine synthase
    UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1
    UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
    UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1
    b4Gal-T1
    beta-1,4-GalTase 1
    beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase
    beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
    beta4Gal-T1
    lactose synthase A protein
    nal synthase
    neolactotriaosylceramide beta-1,4-galactosyltransferase
    NP_445739.1
    XP_038965187.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053287.1NP_445739.1  beta-1,4-galactosyltransferase 1

      See identical proteins and their annotated locations for NP_445739.1

      Status: VALIDATED

      Source sequence(s)
      AA818683, AA956551, AI709691, CB736416, CB741712, CK364907
      UniProtKB/TrEMBL
      A6IIS3, A6IIS4, G3V722
      Related
      ENSRNOP00000069825.1, ENSRNOT00000090499.3
      Conserved Domains (1) summary
      cd00899
      Location:176394
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      60731601..60778456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109259.2XP_038965187.1  beta-1,4-galactosyltransferase 1 isoform X1

      Conserved Domains (1) summary
      pfam13733
      Location:131217
      Glyco_transf_7N; N-terminal region of glycosyl transferase group 7