Scg3 secretogranin III [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Scg3provided by RGD
Official Full Name: secretogranin IIIprovided by RGD
Primary source: RGD:621209
See related: EnsemblRapid:ENSRNOG00000010784 AllianceGenome:RGD:621209
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SgIII
Summary: Predicted to be involved in protein localization to secretory granule. Predicted to be located in extracellular region and transport vesicle membrane. Predicted to be active in secretory granule membrane. Orthologous to human SCG3 (secretogranin III). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 540.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (85280253..85322484, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (76399777..76442015, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (82582352..82641536, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In mast cells, a secretogranin III-chromogranin A complex may play a key role in secretory granule biogenesis.
Title: Secretogranin III directs secretory vesicle biogenesis in mast cells in a manner dependent upon interaction with chromogranin A.
A small amount of secretogranin III is able to sort chromogranin A aggregates together with adrenomedullin to secretory granules.
Title: A large form of secretogranin III functions as a sorting receptor for chromogranin A aggregates in PC12 cells.
SgIII is closely associated with the secretory granule membrane, serving to anchor the aggregates of other soluble constituents to the membrane.
Title: Immunocytochemical localization of secretogranin III in the endocrine pancreas of male rats.
SgIII and CPE form the separate functional sorting complex by anchoring to cholesterol-rich SG membranes, and POMC-derived peptides are transferred from CPE to SgIII, and subsequently to CgA.
Title: Interaction between secretogranin III and carboxypeptidase E facilitates prohormone sorting within secretory granules.
SgIII directly binds to cholesterol components of the secretory granule membrane and targets chromogranin A to secretory granules in pituitary and pancreatic endocrine cells
Title: Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A.

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General gene information

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Markers

AI547406 (e-PCR)
- UniSTS:249799

Scg3 (e-PCR), detects polymorphism
- UniSTS:144373

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in protein localization to secretory granule	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to secretory granule	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to secretory granule	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in secretory granule membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule membrane	IEA Inferred from Electronic Annotation more info
located_in secretory granule membrane	ISO Inferred from Sequence Orthology more info
located_in transport vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: secretogranin-3

Names: 1B1075

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.