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    Tgfb3 transforming growth factor, beta 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25717, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tgfb3provided by RGD
    Official Full Name
    transforming growth factor, beta 3provided by RGD
    Primary source
    RGD:3851
    See related
    EnsemblRapid:ENSRNOG00000009867 AllianceGenome:RGD:3851
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    TGF-B3
    Summary
    Predicted to enable several functions, including cytokine activity; transforming growth factor beta binding activity; and transforming growth factor beta receptor binding activity. Involved in several processes, including regulation of signal transduction; response to estrogen; and skeletal system morphogenesis. Located in several cellular components, including T-tubule; neuronal cell body; and secretory granule. Biomarker of diabetic neuropathy. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 5; arrhythmogenic right ventricular cardiomyopathy; and arrhythmogenic right ventricular dysplasia 1. Orthologous to human TGFB3 (transforming growth factor beta 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 174.2), Muscle (RPKM 94.6) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tgfb3 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (111435170..111457646, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (105704058..105726661, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (109913757..109936217, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ergosterol biosynthesis 28 homolog Neighboring gene tubulin tyrosine ligase like 5 Neighboring gene uncharacterized LOC134479235 Neighboring gene intraflagellar transport 43 Neighboring gene uncharacterized LOC134479452 Neighboring gene G patch domain containing 2-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC105479

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transforming growth factor beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transforming growth factor beta binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transforming growth factor beta receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables type I transforming growth factor beta receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables type I transforming growth factor beta receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables type II transforming growth factor beta receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables type II transforming growth factor beta receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables type III transforming growth factor beta receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables type III transforming growth factor beta receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within animal organ morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-cell junction organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-cell junction organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within cellular response to growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in detection of hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in detection of hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in digestive tract development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in embryonic neurocranium morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in face morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in face morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in female pregnancy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in frontal suture morphogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within_positive_effect gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inner ear development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in lung alveolus development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lung development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within mammary gland development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of macrophage cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of macrophage cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of collagen biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial to mesenchymal transition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tight junction disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of endothelial cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of epithelial cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of epithelial cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    NOT involved_in regulation of epithelial to mesenchymal transition involved in endocardial cushion formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to estrogen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to laminar fluid shear stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to progesterone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to progesterone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within roof of mouth development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in salivary gland morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in salivary gland morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in secondary palate development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in secondary palate development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transforming growth factor beta receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in T-tubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transforming growth factor beta-3 proprotein
    Names
    TGF-beta-3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013174.2NP_037306.1  transforming growth factor beta-3 proprotein preproprotein

      See identical proteins and their annotated locations for NP_037306.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q07258, Q56A31
      UniProtKB/TrEMBL
      A6JE51
      Related
      ENSRNOP00000013516.3, ENSRNOT00000013516.7
      Conserved Domains (2) summary
      cd19386
      Location:312412
      TGF_beta_TGFB3; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-3 (TGF-beta-3) and similar proteins
      pfam00688
      Location:24230
      TGFb_propeptide; TGF-beta propeptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      111435170..111457646 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240366.3XP_006240428.1  transforming growth factor beta-3 proprotein isoform X1

      Conserved Domains (2) summary
      cd19386
      Location:230330
      TGF_beta_TGFB3; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-3 (TGF-beta-3) and similar proteins
      cl02928
      Location:2148
      TGFb_propeptide; TGF-beta propeptide