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    Selenow selenoprotein W [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25545, updated on 9-Dec-2024

    Summary

    Symbol
    Selenowprovided by RGD
    Full Name
    selenoprotein Wprovided by RGD
    Primary source
    RGD:3661
    See related
    EnsemblRapid:ENSRNOG00000051483 AllianceGenome:RGD:3661
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SelW; Sepw1
    Summary
    This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle and brain. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A pseudogene of this locus has been identified on chromosome 10. [provided by RefSeq, Aug 2017]
    Annotation information
    Note: GeneIDs 103689961 and 25545 are annotated independently on Rnor_6.0 but may be redundant loci. [04 May 2017]
    Expression
    Biased expression in Muscle (RPKM 2664.9), Brain (RPKM 1256.7) and 6 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Selenow in Genome Data Viewer
    Location:
    1q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (85727631..85732703, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (76599441..76604514, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (77530692..77535765, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484887 Neighboring gene argininosuccinate synthase 1, pseudogene 1 Neighboring gene ribosomal protein S19-like 3 Neighboring gene ribosomal protein S12-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC105482

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables antioxidant activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to selenium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to selenium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    selenoprotein W
    Names
    selenoprotein W, 1
    selenoprotein W, muscle 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013027.3NP_037159.4  selenoprotein W

      See identical proteins and their annotated locations for NP_037159.4

      Status: REVIEWED

      Source sequence(s)
      BC087625, BI279050, BI281207
      UniProtKB/Swiss-Prot
      P63301
      Related
      ENSRNOP00000112552.1, ENSRNOT00000080422.3
      Conserved Domains (1) summary
      TIGR02174
      Location:577
      CXXU_selWTH; selT/selW/selH selenoprotein domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      85727631..85732703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)