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    Eif2b2 eukaryotic translation initiation factor 2B subunit beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84005, updated on 27-Nov-2024

    Summary

    Official Symbol
    Eif2b2provided by RGD
    Official Full Name
    eukaryotic translation initiation factor 2B subunit betaprovided by RGD
    Primary source
    RGD:620820
    See related
    EnsemblRapid:ENSRNOG00000006467 AllianceGenome:RGD:620820
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Contributes to guanyl-nucleotide exchange factor activity. Involved in several processes, including hippocampus development; positive regulation of axon extension; and response to glucose. Located in axon. Part of eukaryotic translation initiation factor 2B complex. Is active in endoplasmic reticulum; glycinergic synapse; and postsynapse. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter and leukoencephalopathy with vanishing white matter 2. Orthologous to human EIF2B2 (eukaryotic translation initiation factor 2B subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 202.0), Thymus (RPKM 175.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Eif2b2 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (110597979..110604403)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (104866926..104873351)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (109044830..109051254)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene placental growth factor Neighboring gene metallothionein 1, pseudogene 4 Neighboring gene mutL homolog 3 Neighboring gene acylphosphatase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    contributes_to guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in T cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in central nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in central nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cytoplasmic translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytoplasmic translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytoplasmic translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in hippocampus development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in myelination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in myelination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in oligodendrocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in oligodendrocyte development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oligodendrocyte development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ovarian follicle development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ovarian follicle development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of axon extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to glucose IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to heat IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to peptide hormone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of eukaryotic translation initiation factor 2B complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of eukaryotic translation initiation factor 2B complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of eukaryotic translation initiation factor 2B complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of eukaryotic translation initiation factor 2B complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of eukaryotic translation initiation factor 2B complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in glycinergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    translation initiation factor eIF2B subunit beta
    Names
    eIF-2B GDP-GTP exchange factor subunit beta
    eIF2B GDP-GTP exchange factor subunit beta
    eukaryotic translation initiation factor 2B subunit 2
    eukaryotic translation initiation factor 2B, subunit 2 (beta, 39kD)
    eukaryotic translation initiation factor 2B, subunit 2 beta
    translation initiation factor eIF-2B subunit beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032058.2NP_114447.2  translation initiation factor eIF2B subunit beta

      See identical proteins and their annotated locations for NP_114447.2

      Status: PROVISIONAL

      Source sequence(s)
      BC070506
      UniProtKB/Swiss-Prot
      O08956, Q62818
      UniProtKB/TrEMBL
      Q6IRS8
      Related
      ENSRNOP00000008730.2, ENSRNOT00000008730.6
      Conserved Domains (2) summary
      COG1184
      Location:13344
      GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
      pfam01008
      Location:29333
      IF-2B; Initiation factor 2 subunit family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      110597979..110604403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)