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    Kif2c kinesin family member 2C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171529, updated on 3-Dec-2024

    Summary

    Official Symbol
    Kif2cprovided by RGD
    Official Full Name
    kinesin family member 2Cprovided by RGD
    Primary source
    RGD:620239
    See related
    EnsemblRapid:ENSRNOG00000019100 AllianceGenome:RGD:620239
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    KRP2; MCAK
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule motor activity; and microtubule plus-end binding activity. Predicted to be involved in several processes, including attachment of mitotic spindle microtubules to kinetochore; cytoskeleton organization; and regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Predicted to be located in cytoplasmic microtubule; kinetochore; and microtubule plus-end. Predicted to be part of kinesin complex. Predicted to be active in several cellular components, including glutamatergic synapse; microtubule cytoskeleton; and postsynapse. Orthologous to human KIF2C (kinesin family member 2C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 242.3), Thymus (RPKM 120.0) and 2 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Kif2c in Genome Data Viewer
    Location:
    5q36
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (135873925..135899267, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (130637347..130662680, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (136027923..136053268, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S8 Neighboring gene small nucleolar RNA, C/D box 46 Neighboring gene small nucleolar RNA, C/D box 55 Neighboring gene transfer RNA alanine (anticodon AGC) 53 Neighboring gene U5 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule plus-end binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule plus-end binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule plus-end binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in attachment of mitotic spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in attachment of mitotic spindle microtubules to kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment or maintenance of microtubule cytoskeleton polarity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment or maintenance of microtubule cytoskeleton polarity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in metaphase chromosome alignment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in microtubule depolymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic metaphase chromosome alignment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in postsynaptic cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in postsynaptic cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule plus-end IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule plus-end ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    kinesin-like protein KIF2C
    Names
    kinesin-related protein 2
    mitotic centromere-associated kinesin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085369.2NP_001078838.1  kinesin-like protein KIF2C isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      FN805204, JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q62909
      Related
      ENSRNOP00000025903.6, ENSRNOT00000025903.9
      Conserved Domains (2) summary
      cd01367
      Location:254582
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
      pfam00225
      Location:260583
      Kinesin; Kinesin motor domain
    2. NM_001305429.1NP_001292358.1  kinesin-like protein KIF2C isoform 3

      See identical proteins and their annotated locations for NP_001292358.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at an alternate start codon, and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1, but has an additional internal amino acid.
      Source sequence(s)
      FN805204, JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q62909
      UniProtKB/TrEMBL
      A6JZD0
      Conserved Domains (2) summary
      cd01367
      Location:204532
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
      pfam00225
      Location:210533
      Kinesin; Kinesin motor domain
    3. NM_134472.4NP_608302.2  kinesin-like protein KIF2C isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      FN805204, JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q62909
      Conserved Domains (2) summary
      cd01367
      Location:203531
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
      pfam00225
      Location:209532
      Kinesin; Kinesin motor domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      135873925..135899267 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238632.5XP_006238694.1  kinesin-like protein KIF2C isoform X1

      UniProtKB/Swiss-Prot
      Q62909
      UniProtKB/TrEMBL
      D3ZQG8
      Conserved Domains (2) summary
      cd01367
      Location:255583
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
      pfam00225
      Location:261584
      Kinesin; Kinesin motor domain
    2. XM_063287143.1XP_063143213.1  kinesin-like protein KIF2C isoform X5

      UniProtKB/Swiss-Prot
      Q62909
    3. XM_006238633.4XP_006238695.1  kinesin-like protein KIF2C isoform X2

      UniProtKB/Swiss-Prot
      Q62909
      UniProtKB/TrEMBL
      F1M457
      Conserved Domains (1) summary
      cd01367
      Location:207535
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    4. XM_063287141.1XP_063143211.1  kinesin-like protein KIF2C isoform X4

      UniProtKB/Swiss-Prot
      Q62909
      UniProtKB/TrEMBL
      A6JZD0
    5. XM_063287142.1XP_063143212.1  kinesin-like protein KIF2C isoform X5

      UniProtKB/Swiss-Prot
      Q62909
    6. XM_063287140.1XP_063143210.1  kinesin-like protein KIF2C isoform X4

      UniProtKB/Swiss-Prot
      Q62909
      UniProtKB/TrEMBL
      A6JZD0
    7. XM_017593141.3XP_017448630.1  kinesin-like protein KIF2C isoform X2

      UniProtKB/Swiss-Prot
      Q62909
      UniProtKB/TrEMBL
      F1M457
      Conserved Domains (1) summary
      cd01367
      Location:207535
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    8. XM_063287139.1XP_063143209.1  kinesin-like protein KIF2C isoform X3

      UniProtKB/Swiss-Prot
      Q62909
    9. XM_039109239.2XP_038965167.1  kinesin-like protein KIF2C isoform X2

      UniProtKB/Swiss-Prot
      Q62909
      UniProtKB/TrEMBL
      F1M457
      Related
      ENSRNOP00000061433.4, ENSRNOT00000068395.5
      Conserved Domains (1) summary
      cd01367
      Location:207535
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group