Adra2a adrenoceptor alpha 2A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adra2aprovided by RGD
Official Full Name: adrenoceptor alpha 2Aprovided by RGD
Primary source: RGD:2056
See related: EnsemblRapid:ENSRNOG00000047545 AllianceGenome:RGD:2056
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RG20; CA2-47; RATRG20
Summary: Enables alpha2-adrenergic receptor activity. Involved in several processes, including negative regulation of secretion by cell; negative regulation of uterine smooth muscle contraction; and response to morphine. Located in axon terminus and neuronal cell body. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Used to study anxiety disorder and depressive disorder. Biomarker of alcohol dependence; hypertension; morphine dependence; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; attention deficit hyperactivity disorder; familial partial lipodystrophy; nicotine dependence; and type 2 diabetes mellitus. Orthologous to human ADRA2A (adrenoceptor alpha 2A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: 1q55

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (263066780..263069580)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (253061480..253064280)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (274766283..274769083)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression and localization of alpha2A-adrenergic receptor in the rat post-natal developing cochlea.
Title: Expression and localization of α(2A)-adrenergic receptor in the rat post-natal developing cochlea.
Results suggest that alpha-2A adrenergic receptor (alpha2-adrenoceptors) in the prelimbic cortex (PrL) are involved in the regulation of anxiety-like behaviors.
Title: Activation and blockade of α(2)-adrenoceptors in the prelimbic cortex regulate anxiety-like behaviors in hemiparkinsonian rats.
Adra2a signaling is impaired in the cardiomyocytes of spontaneously hypertensive rats starting from 2 months old.
Title: α2-Adrenoceptor signaling in cardiomyocytes of spontaneously hypertensive rats starts to impair already at early age.
chronic testosterone influences impulsivity possibly via hyperactive alpha-2A adrenergic receptor-PKA signaling axis.
Title: Chronic Testosterone Increases Impulsivity and Influences the Transcriptional Activity of the Alpha-2A Adrenergic Receptor Signaling Pathway in Rat Brain.
It is concluded that activation of alpha2A-adrenergic signal in chondrocytes promotes temporomandibular joint degenerative remodelling by chondrocyte-mediated pro-catabolic activities.
Title: Activation of α2A-adrenergic signal transduction in chondrocytes promotes degenerative remodelling of temporomandibular joint.
the excitatory input and post-synaptic dynamics of pontine reticular nucleus reticulospinal neurons are indeed intricately modulated by the activation of alpha1- and alpha2-adrenoceptors.
Title: Adrenoceptor-Mediated Post- and Pre-Synaptic Regulations of the Reticulospinal Neurons in Rat Caudal Pontine Reticular Nucleus.
Study showed that alpha2A adrenergic receptors are highly expressed in the cell bodies and axons of mesoprefrontal dopaminergic neurons provides a morphological basis to the vast functional evidence that somatodendritic and nerve-terminal alpha2A adrenergic receptors control dopaminergic activity and dopamine release in the prefrontal cortex.
Title: α2A adrenergic receptors highly expressed in mesoprefrontal dopamine neurons.
Data show that the central alpha2 receptor agonists clonidine and dexmedetomidine are effective to attenuate local and systemic injury in experimental severe necrotizing pancreatitis (SNP) and should be evaluated in the clinical setting.
Title: Stimulation of Central α2 Receptors Attenuates Experimental Necrotizing Pancreatitis.
Report specific roles of alpha2A - and alpha2B -, but not alpha2C -, adrenoceptor subtypes in the inhibition of the vasopressor sympathetic out-flow in diabetic pithed rats.
Title: Specific role of α2A - and α2B -, but not α2C -, adrenoceptor subtypes in the inhibition of the vasopressor sympathetic out-flow in diabetic pithed rats.
Results provide support for a link between early-life stress, susceptibility for high alcohol consumption, and low Adra2a expression in the hypothalamus.
Title: Αlpha 2a-Adrenoceptor Gene Expression and Early Life Stress-Mediated Propensity to Alcohol Drinking in Outbred Rats.

Submit: New GeneRIF Correction See all GeneRIFs (53)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH139989 (e-PCR)
- UniSTS:222071

D1Smu2 (e-PCR)
- UniSTS:517805

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables adrenergic receptor activity	ISO Inferred from Sequence Orthology more info
enables alpha-1B adrenergic receptor binding	ISO Inferred from Sequence Orthology more info
enables alpha-2C adrenergic receptor binding	ISO Inferred from Sequence Orthology more info
enables alpha2-adrenergic receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha2-adrenergic receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha2-adrenergic receptor activity	ISO Inferred from Sequence Orthology more info
enables epinephrine binding	IBA Inferred from Biological aspect of Ancestor more info
enables epinephrine binding	ISO Inferred from Sequence Orthology more info
enables heterotrimeric G-protein binding	ISO Inferred from Sequence Orthology more info
enables norepinephrine binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables thioesterase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in activation of protein kinase B activity	ISO Inferred from Sequence Orthology more info
involved_in activation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hormone stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fear response	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium ion-dependent exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of uterine smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in platelet activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of wound healing	ISO Inferred from Sequence Orthology more info
involved_in presynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
involved_in response to alcohol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to morphine	IEP Inferred from Expression Pattern more info	PubMed
involved_in thermoception	IDA Inferred from Direct Assay more info	PubMed
involved_in vasodilation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in dopaminergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	EXP Inferred from Experiment more info	PubMed
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-2A adrenergic receptor

Names: adrenergic receptor, alpha 2a; adrenergic, alpha-2A-, receptor; alpha-2A adrenoceptor; alpha-2A adrenoreceptor; alpha-2AAR; alpha-2D adrenergic receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012739.3 → NP_036871.3 alpha-2A adrenergic receptor

See identical proteins and their annotated locations for NP_036871.3

Status: VALIDATED

Source sequence(s)

AW915790, AW919837, CB584098, CB763650, CO574013, U49747, U79031

UniProtKB/Swiss-Prot

M0R9R3, P22909

Related

ENSRNOP00000066242.1, ENSRNOT00000071541.3

Conserved Domains (2) summary

PRK07764
Location:243 → 365

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd15322
Location:49 → 452

7tmA_alpha2A_AR; alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors