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    Pnpo pyridoxamine 5'-phosphate oxidase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64533, updated on 27-Nov-2024

    Summary

    Official Symbol
    Pnpoprovided by RGD
    Official Full Name
    pyridoxamine 5'-phosphate oxidaseprovided by RGD
    Primary source
    RGD:621456
    See related
    EnsemblRapid:ENSRNOG00000046493 AllianceGenome:RGD:621456
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables pyridoxamine phosphate oxidase activity. Predicted to be involved in pyridoxal phosphate biosynthetic process and pyridoxamine metabolic process. Predicted to be located in mitochondrion. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in pyridoxamine 5'-phosphate oxidase deficiency. Orthologous to human PNPO (pyridoxamine 5'-phosphate oxidase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 157.2), Heart (RPKM 156.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Pnpo in Genome Data Viewer
    Location:
    10q31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (82421027..82427288, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (81924584..81930844, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (84874926..84881190, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene CDK5 regulatory subunit associated protein 3 Neighboring gene uncharacterized LOC134480861 Neighboring gene proline rich 15-like Neighboring gene uncharacterized LOC102547955 Neighboring gene Sp2 transcription factor Neighboring gene uncharacterized LOC108352124

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC93433

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables FMN binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyridoxal phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyridoxamine phosphate oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pyridoxamine phosphate oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pyridoxamine phosphate oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in pyridoxal phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in pyridoxal phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pyridoxal phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pyridoxamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pyridoxine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    pyridoxine-5'-phosphate oxidase
    Names
    pyridoxamine-phosphate oxidase
    pyridoxine 5-phosphate oxidase
    NP_072123.1
    XP_063125888.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022601.4NP_072123.1  pyridoxine-5'-phosphate oxidase

      See identical proteins and their annotated locations for NP_072123.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      O88794
      UniProtKB/TrEMBL
      A6HIH6
      Related
      ENSRNOP00000067069.1, ENSRNOT00000073746.3
      Conserved Domains (1) summary
      TIGR00558
      Location:57261
      pdxH; pyridoxamine-phosphate oxidase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      82421027..82427288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269818.1XP_063125888.1  pyridoxine-5'-phosphate oxidase isoform X1