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    Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84026, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dnaja2provided by RGD
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member A2provided by RGD
    Primary source
    RGD:71001
    See related
    EnsemblRapid:ENSRNOG00000016251 AllianceGenome:RGD:71001
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dj3; Cpr3; DjA2; Dnj3; Rdj2; Hirip4
    Summary
    Predicted to enable ATPase activator activity; protein-folding chaperone binding activity; and unfolded protein binding activity. Involved in carbon tetrachloride metabolic process. Predicted to be located in membrane. Predicted to be active in cytosol. Biomarker of liver disease. Orthologous to human DNAJA2 (DnaJ heat shock protein family (Hsp40) member A2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 512.5), Heart (RPKM 468.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Dnaja2 in Genome Data Viewer
    Location:
    19p11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (37671019..37689163)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (21497792..21516904)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (22569999..22588143)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene integrin alpha FG-GAP repeat containing 1 Neighboring gene uncharacterized LOC134483303 Neighboring gene neuropilin and tolloid like 2 Neighboring gene uncharacterized LOC102548349 Neighboring gene glutamic--pyruvic transaminase 2 Neighboring gene uncharacterized LOC120098665

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC93325

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in carbon tetrachloride metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein refolding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein refolding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to heat IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dnaJ homolog subfamily A member 2
    Names
    DnaJ (Hsp40) homolog, subfamily A, member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032079.2NP_114468.2  dnaJ homolog subfamily A member 2

      See identical proteins and their annotated locations for NP_114468.2

      Status: PROVISIONAL

      Source sequence(s)
      BC087010
      UniProtKB/Swiss-Prot
      O35824
      UniProtKB/TrEMBL
      F7F428, Q5M9H7
      Related
      ENSRNOP00000022573.3, ENSRNOT00000022573.7
      Conserved Domains (1) summary
      PTZ00037
      Location:4412
      PTZ00037; DnaJ_C chaperone protein; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      37671019..37689163
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)