U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Gpx1 glutathione peroxidase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24404, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gpx1provided by RGD
    Official Full Name
    glutathione peroxidase 1provided by RGD
    Primary source
    RGD:2729
    See related
    EnsemblRapid:ENSRNOG00000048812 AllianceGenome:RGD:2729
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GSHPx; GSHPx-1
    Summary
    The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Jul 2016]
    Expression
    Biased expression in Liver (RPKM 6858.1), Heart (RPKM 3806.1) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gpx1 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (117905462..117906588)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (109026905..109028031)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117117430..117118528)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene U6 snRNA-associated Sm-like protein LSm3 Neighboring gene ras homolog family member A Neighboring gene ribosomal protein S15a, pseudogene 7 Neighboring gene ubiquitin specific peptidase 4 Neighboring gene similar to human chromosome 3 open reading frame 62

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutathione peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glutathione peroxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glutathione peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables glutathione peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipid-hydroperoxide glutathione peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipid-hydroperoxide glutathione peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipid-hydroperoxide glutathione peroxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in UV protection IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in UV protection ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in angiogenesis involved in wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within angiogenesis involved in wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in arachidonate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in arachidonate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in arachidonate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in biological process involved in interaction with symbiont IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within biological process involved in interaction with symbiont ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in blood vessel endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell redox homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glucose stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endothelial cell development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within endothelial cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epigenetic regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epigenetic regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glutathione metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glutathione metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heart contraction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hydrogen peroxide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in hydrogen peroxide catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within hydrogen peroxide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hydrogen peroxide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of intrinsic apoptotic signaling pathway in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipoxygenase pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipoxygenase pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipoxygenase pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in myoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myoblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within myoblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within myotube differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of inflammatory response to antigenic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of release of cytochrome c from mitochondria IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mammary gland epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mammary gland epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of proteasomal protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to folic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to gamma radiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to glucose IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hydrogen peroxide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hydroperoxide IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to hydroperoxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to nicotine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to selenium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to selenium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to selenium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to selenium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to symbiotic bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to symbiotic bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to toxic substance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to vitamin E IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within response to wounding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sensory perception of sound IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal muscle fiber development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within skeletal muscle fiber development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal muscle tissue regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within skeletal muscle tissue regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in temperature homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within temperature homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in triglyceride metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vasodilation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within vasodilation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Lewy body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Lewy body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glutathione peroxidase 1
    Names
    GPx-1
    cellular glutathione peroxidase
    phospholipid-hydroperoxide glutathione peroxidase GPX1
    NP_110453.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030826.4NP_110453.3  glutathione peroxidase 1

      See identical proteins and their annotated locations for NP_110453.3

      Status: REVIEWED

      Source sequence(s)
      FQ139913, FQ231953
      UniProtKB/Swiss-Prot
      O08946, P04041, Q4PIY2, Q91WZ5
      UniProtKB/TrEMBL
      M0RAM5
      Related
      ENSRNOP00000066577.3, ENSRNOT00000073247.4
      Conserved Domains (1) summary
      cd00340
      Location:13190
      GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      117905462..117906588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)