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    Gamt guanidinoacetate N-methyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25257, updated on 3-Dec-2024

    Summary

    Official Symbol
    Gamtprovided by RGD
    Official Full Name
    guanidinoacetate N-methyltransferaseprovided by RGD
    Primary source
    RGD:2659
    See related
    EnsemblRapid:ENSRNOG00000024577 AllianceGenome:RGD:2659
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GMT
    Summary
    Enables guanidinoacetate N-methyltransferase activity and identical protein binding activity. Involved in S-adenosylmethionine metabolic process; carboxylic acid metabolic process; and embryonic liver development. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and guanidinoacetate methyltransferase deficiency. Orthologous to human GAMT (guanidinoacetate N-methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 1351.4), Kidney (RPKM 300.0) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gamt in Genome Data Viewer
    Location:
    7q11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10099267..10102083)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9448590..9451413)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12314848..12317998)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S15 Neighboring gene DAZ associated protein 1 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S7 Neighboring gene transfer RNA asparagine (anticodon GUU) 8 Neighboring gene transfer RNA phenylalanine (anticodon GAA) 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in S-adenosylhomocysteine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in S-adenosylmethionine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in animal organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within animal organ morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in creatine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in creatine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in creatine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within creatine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in creatine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in creatine biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in embryonic liver development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    guanidinoacetate N-methyltransferase
    Names
    guanidinoacetate methyltransferase
    NP_001389142.1
    NP_036925.2
    XP_038934381.1
    XP_063119080.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402213.1NP_001389142.1  guanidinoacetate N-methyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      Related
      ENSRNOP00000036927.3, ENSRNOT00000028969.6
    2. NM_012793.3NP_036925.2  guanidinoacetate N-methyltransferase isoform 1

      See identical proteins and their annotated locations for NP_036925.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      P10868
      UniProtKB/TrEMBL
      A6K8N3, G3V960
      Conserved Domains (1) summary
      cd02440
      Location:63166
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10099267..10102083
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078453.2XP_038934381.1  guanidinoacetate N-methyltransferase isoform X2

      Conserved Domains (1) summary
      cd02440
      Location:63157
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. XM_063263010.1XP_063119080.1  guanidinoacetate N-methyltransferase isoform X1

      UniProtKB/Swiss-Prot
      P10868