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    Rpl18a ribosomal protein L18A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290641, updated on 3-Dec-2024

    Summary

    Official Symbol
    Rpl18aprovided by RGD
    Official Full Name
    ribosomal protein L18Aprovided by RGD
    Primary source
    RGD:1302976
    See related
    EnsemblRapid:ENSRNOG00000018795 AllianceGenome:RGD:1302976
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be a structural constituent of ribosome. Involved in response to antineoplastic agent. Located in ribosome. Part of cytosolic large ribosomal subunit. Is active in postsynaptic density. Biomarker of alcohol use disorder. Orthologous to human RPL18A (ribosomal protein L18a). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 4484.6), Thymus (RPKM 4155.8) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rpl18a in Genome Data Viewer
    Location:
    16p14
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18576467..18578653)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18542555..18544578)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20293277..20295283)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein 1S Neighboring gene uncharacterized LOC134482467 Neighboring gene small nucleolar RNA SNORA68 Neighboring gene solute carrier family 5 member 5 Neighboring gene uncharacterized LOC134482469 Neighboring gene coiled-coil domain containing 124

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC72957

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to antineoplastic agent IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    large ribosomal subunit protein eL20
    Names
    60S ribosomal protein L18a

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212510.3NP_997675.1  large ribosomal subunit protein eL20

      See identical proteins and their annotated locations for NP_997675.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      P62718
      UniProtKB/TrEMBL
      A6K9Y4, F1M0K6
      Conserved Domains (1) summary
      COG2157
      Location:69153
      RPL20A; Ribosomal protein L20A (L18A) [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      18576467..18578653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275155.1XP_063131225.1  large ribosomal subunit protein eL20 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AM85, A6K9Y3
      Related
      ENSRNOP00000025421.5, ENSRNOT00000025421.8