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    Rplp0 ribosomal protein lateral stalk subunit P0 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64205, updated on 27-Nov-2024

    Summary

    Official Symbol
    Rplp0provided by RGD
    Official Full Name
    ribosomal protein lateral stalk subunit P0provided by RGD
    Primary source
    RGD:621247
    See related
    EnsemblRapid:ENSRNOG00000001148 AllianceGenome:RGD:621247
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Arbp
    Summary
    Enables peptide binding activity. Involved in several processes, including cellular response to Thyroid stimulating hormone; cellular response to cAMP; and cellular response to phorbol 13-acetate 12-myristate. Is active in synapse. Biomarker of Down syndrome. Orthologous to several human genes including RPLP0 (ribosomal protein lateral stalk subunit P0). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 7984.4), Thymus (RPKM 6072.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rplp0 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (46715121..46718390, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (41054363..41057632, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (46791528..46794797, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene RAB35, member RAS oncogene family Neighboring gene uncharacterized LOC120096002 Neighboring gene GCN1 activator of EIF2AK4 Neighboring gene paxillin Neighboring gene ribosomal protein S5, pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables large ribosomal subunit rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to Thyroid stimulating hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to cAMP IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to interleukin-4 ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to phorbol 13-acetate 12-myristate IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lactation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to selenium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in translation at postsynapse NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in translation at presynapse NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynapse NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in ribosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    large ribosomal subunit protein uL10
    Names
    60S acidic ribosomal protein P0
    60S ribosomal protein L10E
    acidic ribosomal phosphoprotein P0
    ribosomal protein, large, P0

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022402.2NP_071797.1  large ribosomal subunit protein uL10

      See identical proteins and their annotated locations for NP_071797.1

      Status: VALIDATED

      Source sequence(s)
      BP465362, DN931898, JAXUCZ010000012
      UniProtKB/Swiss-Prot
      P19945
      UniProtKB/TrEMBL
      A6J1T4
      Related
      ENSRNOP00000001518.3, ENSRNOT00000001518.8
      Conserved Domains (2) summary
      cd05795
      Location:9182
      Ribosomal_P0_L10e; Ribosomal protein L10 family, P0 and L10e subfamily; composed of eukaryotic 60S ribosomal protein P0 and the archaeal P0 homolog, L10e. P0 or L10e forms a tight complex with multiple copies of the small acidic protein L12(e). This complex forms a stalk ...
      PTZ00135
      Location:1317
      PTZ00135; 60S acidic ribosomal protein P0; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      46715121..46718390 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)