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    Lmna lamin A/C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60374, updated on 3-Dec-2024

    Summary

    Official Symbol
    Lmnaprovided by RGD
    Official Full Name
    lamin A/Cprovided by RGD
    Primary source
    RGD:620456
    See related
    EnsemblRapid:ENSRNOG00000019638 AllianceGenome:RGD:620456
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables protein phosphatase 1 binding activity. Involved in several processes, including cellular senescence; negative regulation of adipose tissue development; and positive regulation of osteoblast differentiation. Located in nuclear envelope and nuclear matrix. Used to study transient cerebral ischemia. Biomarker of arteriosclerosis. Human ortholog(s) of this gene implicated in several diseases, including Werner syndrome; intrinsic cardiomyopathy (multiple); lipodystrophy (multiple); neuromuscular disease (multiple); and type 2 diabetes mellitus (multiple). Orthologous to human LMNA (lamin A/C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 472.1), Lung (RPKM 385.2) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Lmna in Genome Data Viewer
    Location:
    2q34
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (176237564..176265301, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (173939751..173960423, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187842884..187863552, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485636 Neighboring gene semaphorin 4A Neighboring gene uncharacterized LOC120100862 Neighboring gene mex-3 RNA binding family member A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase 1 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of nuclear lamina IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of nuclear lamina ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural constituent of nuclear lamina ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in DNA double-strand break attachment to nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA double-strand break attachment to nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA double-strand break attachment to nuclear envelope ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular senescence IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular senescence IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within_positive_effect cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within_positive_effect cellular senescence ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in establishment or maintenance of microtubule cytoskeleton polarity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment or maintenance of microtubule cytoskeleton polarity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in muscle organ development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of adipose tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cardiac muscle hypertrophy in response to stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cardiac muscle hypertrophy in response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cardiac muscle hypertrophy in response to stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mesenchymal cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of mesenchymal cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of release of cytochrome c from mitochondria IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear envelope organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nuclear envelope organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within nuclear envelope organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear envelope organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear envelope organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nuclear pore localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within nucleus organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization to nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein stability IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in ventricular cardiac muscle cell development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within ventricular cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamin filament IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamin filament ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nuclear lamina IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear lamina IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nuclear lamina ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nuclear lamina ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in site of double-strand break IEA
    Inferred from Electronic Annotation
    more info
     
    located_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     
    located_in site of double-strand break ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    prelamin-A/C
    Names
    lamin A
    lamin C2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002016.2NP_001002016.2  prelamin-A/C

      See identical proteins and their annotated locations for NP_001002016.2

      Status: VALIDATED

      Source sequence(s)
      CA338388, DN934590, FM031779, FM060776, JAXUCZ010000002
      UniProtKB/Swiss-Prot
      P48679
      UniProtKB/TrEMBL
      A6J680, G3V8L3
      Conserved Domains (2) summary
      pfam00038
      Location:30386
      Filament; Intermediate filament protein
      pfam00932
      Location:434541
      LTD; Lamin Tail Domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      176237564..176265301 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282429.1XP_063138499.1  prelamin-A/C isoform X1

      UniProtKB/Swiss-Prot
      P48679
      UniProtKB/TrEMBL
      A6J680, G3V8L3
      Related
      ENSRNOP00000026705.5, ENSRNOT00000026705.8

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_021755.1: Suppressed sequence

      Description
      NM_021755.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.