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    Mst1 macrophage stimulating 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24566, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mst1provided by RGD
    Official Full Name
    macrophage stimulating 1provided by RGD
    Primary source
    RGD:3114
    See related
    EnsemblRapid:ENSRNOG00000019680 AllianceGenome:RGD:3114
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    E2F2
    Summary
    Enables enzyme binding activity and histone kinase activity. Involved in several processes, including cellular response to hypoxia; cellular response to type II interferon; and flagellated sperm motility. Predicted to be located in vacuole. Predicted to be active in extracellular space. Orthologous to several human genes including MST1 (macrophage stimulating 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 716.5), Adrenal (RPKM 80.4) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mst1 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (117646485..117652016)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (108767886..108773425)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (116857716..116862286)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene cadherin-related family member 4 Neighboring gene inositol hexakisphosphate kinase 1 Neighboring gene GDP-mannose pyrophosphorylase B Neighboring gene ring finger protein 123 Neighboring gene adhesion molecule with Ig like domain 3 Neighboring gene acylaminoacyl-peptide hydrolase Neighboring gene bassoon (presynaptic cytomatrix protein)

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables receptor tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to type II interferon IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within embryo implantation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in flagellated sperm motility IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within mammary duct terminal end bud growth ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mammary gland development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of mammary gland epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein modification process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cAMP-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of macrophage chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vacuole ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    hepatocyte growth factor-like protein
    Names
    D8h3f15s2
    E2F transcription factor 2
    Macrophage stimulating 1 (hepatocyte growth factor-like)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024352.1NP_077328.1  hepatocyte growth factor-like protein precursor

      See identical proteins and their annotated locations for NP_077328.1

      Status: PROVISIONAL

      Source sequence(s)
      X95096
      UniProtKB/TrEMBL
      F7FMS0, P70521, Q5EBC6
      Related
      ENSRNOP00000026711.5, ENSRNOT00000026711.9
      Conserved Domains (4) summary
      smart00020
      Location:488709
      Tryp_SPc; Trypsin-like serine protease
      smart00130
      Location:377459
      KR; Kringle domain
      cd00190
      Location:489712
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00024
      Location:25103
      PAN_1; PAN domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      117646485..117652016
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080802.2XP_038936730.1  hepatocyte growth factor-like protein isoform X2

      UniProtKB/TrEMBL
      F7FMS0
      Conserved Domains (2) summary
      smart00130
      Location:328410
      KR; Kringle domain
      cd00190
      Location:440663
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. XM_039080801.2XP_038936729.1  hepatocyte growth factor-like protein isoform X1

      UniProtKB/TrEMBL
      F7FMS0
      Conserved Domains (3) summary
      smart00130
      Location:408490
      KR; Kringle domain
      cd00190
      Location:520743
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00024
      Location:32111
      PAN_1; PAN domain