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    Ddt D-dopachrome tautomerase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29318, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ddtprovided by RGD
    Official Full Name
    D-dopachrome tautomeraseprovided by RGD
    Primary source
    RGD:61923
    See related
    EnsemblRapid:ENSRNOG00000083406 AllianceGenome:RGD:61923
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables D-dopachrome decarboxylase activity. Predicted to be involved in several processes, including negative regulation of macrophage chemotaxis; positive regulation of ERK1 and ERK2 cascade; and positive regulation of tumor necrosis factor production. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Orthologous to several human genes including DDT (D-dopachrome tautomerase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 1896.0), Kidney (RPKM 1045.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ddt in Genome Data Viewer
    Location:
    20p12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (12883025..12886121)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (12884216..12886687)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (13827153..13829624)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase theta 1 Neighboring gene uncharacterized LOC134483890 Neighboring gene glutathione S-transferase, theta 3 Neighboring gene calcineurin binding protein 1 Neighboring gene uncharacterized LOC102556116 Neighboring gene sushi domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables D-dopachrome decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables D-dopachrome decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables dopachrome isomerase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables phenylpyruvate tautomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phenylpyruvate tautomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    D-dopachrome decarboxylase
    Names
    dopachrome isomerase
    NP_077045.1
    XP_063135059.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024131.2NP_077045.1  D-dopachrome decarboxylase

      See identical proteins and their annotated locations for NP_077045.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      P80254
      UniProtKB/TrEMBL
      A0A0F7RQJ6, A6JKH4
      Conserved Domains (1) summary
      pfam01187
      Location:2116
      MIF; Macrophage migration inhibitory factor (MIF)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      12883025..12886121
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278989.1XP_063135059.1  D-dopachrome decarboxylase isoform X1

      Related
      ENSRNOP00000107743.1, ENSRNOT00000151293.1